Ramsay D M, Robertson E P, MacArthur E
J Clin Pathol. 1977 Aug;30(8):766-9. doi: 10.1136/jcp.30.8.766.
The value of different anticoagulants as preservatives of specimens for prothrombin time ratios is evaluated and discussed. An increase in the ratio was demonstrated with all anti-coagulants after 24 hours and this was significant when coagulometer error was taken into account. Both solid and liquid sodium citrate were superior to sodium oxalate as preservatives at 24 hours after taking off samples, but differences were slight and were not significant when coagulometer error was considered. It was concluded that for routine clinical practice, where a range of the prothrombin time ratio of 1.8/1 to 2.5/1 is allowable, there would be no significant advantage in any of the anticoagulants considered.
评估并讨论了不同抗凝剂作为凝血酶原时间比值标本防腐剂的价值。24小时后，所有抗凝剂的比值均有所增加，考虑到凝固计误差时，这一增加具有显著性。在采血后24小时，固体和液体柠檬酸钠作为防腐剂均优于草酸钠，但差异微小，考虑凝固计误差时无显著性。结论是，对于常规临床实践，凝血酶原时间比值范围在1.8/1至2.5/1之间是允许的，在所考虑的任何一种抗凝剂中均无显著优势。
