Creasia D A
J Toxicol Environ Health. 1977 Dec;3(5-6):1003-10. doi: 10.1080/15287397709529634.
The effect of respiratory infection by PR8 influenza virus on the elution of bnezo[a]pyrene (BaP) from carbon particles in the respiratory tract of mice was studied. In mice, this virus produces, among other pheneomena, a proteinaceous effusion and mixed cellular exudate in the alveolar parenchyma during the acute phase of infection. If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased. When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles were similar to that in uninfected animals.
研究了PR8流感病毒引起的呼吸道感染对小鼠呼吸道中碳颗粒上苯并[a]芘（BaP）洗脱的影响。在小鼠中，这种病毒在感染急性期除了产生其他现象外，还会在肺泡实质中产生蛋白质渗出液和混合细胞渗出物。如果在感染急性期将涂有BaP的碳颗粒引入呼吸道，碳颗粒上BaP的洗脱速率会增加。当在感染急性期前1周或急性期后2周将涂有BaP的碳颗粒滴入呼吸道时，碳颗粒上BaP的洗脱速率与未感染动物相似。
