Rosiello A P, Essignmann J M, Wogan G N
J Toxicol Environ Health. 1977 Dec;3(5-6):797-809. doi: 10.1080/15287397709529614.
A program for a small digital computer was developed to calculate the median lethal dose (LD50) and its errors. The algorithm employed in the program was based on a method described by Bliss. Modifications introduced by Finney are also discussed. The results indicate a high degree of accuracy compared with calculations performed by Bliss. The accuracy and speed of calculation exceeded those possible with simplified and graphic methods. The data and results for four toxic compounds are presented.
开发了一个用于小型数字计算机的程序，以计算半数致死剂量（LD50）及其误差。该程序中采用的算法基于布利斯描述的一种方法。还讨论了芬尼引入的修改。结果表明，与布利斯进行的计算相比，该方法具有高度的准确性。计算的准确性和速度超过了简化方法和图解法所能达到的程度。给出了四种有毒化合物的数据和结果。
