[Geometrical method for assessing the interaction of the antidote and the poison in a model experiment].
作者信息
Prozorovskiĭ V B
出版信息
Farmakol Toksikol. 1987 May-Jun;50(3):110-2.
PMID:3609268
Abstract
A method of construction of isobologram and its approximation is proposed for a quantitative assessment of the relationship between a change in LD50 of one substance (poison) and increasing doses of other (antidote). It is recommended to determine the coefficient of the action of the substances on each other. Its value in cases of antagonism is in the range of from 0 to - infinity and in cases of synergism from 0 to + infinity. A formula for the calculation of the coefficient and a geometrical method for the determination of its value are given. The method assumes the identification of a mean error of the coefficient and its confidence limits.
摘要
相似文献
1
[Geometrical method for assessing the interaction of the antidote and the poison in a model experiment].
Farmakol Toksikol. 1987 May-Jun;50(3):110-2.
2
Statistical analysis of drug interactions.药物相互作用的统计分析
NIDA Res Monogr. 1986;68:41-64.
3
[The selection of the indices of antidote efficacy].[解毒剂疗效指标的选择]
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):43-5.
4
[Interaction of atropine, toxogonin and fosfakol].[阿托品、氯磷定和磷胺的相互作用]
Farmakol Toksikol. 1984 Mar-Apr;47(2):33-7.
5
6
Rapid and accurate determination of the median lethal dose (LD50) and its error with a small computer.用小型计算机快速准确地测定半数致死剂量（LD50）及其误差。
J Toxicol Environ Health. 1977 Dec;3(5-6):797-809. doi: 10.1080/15287397709529614.
7
[Method of determining the median lethal doses and concentrations of chemical substances].
Gig Sanit. 1980 Oct(10):49-51.
8
[The use of a complex cobalt compound as a cyanide antidote].[一种复合钴化合物作为氰化物解毒剂的应用]
Eksp Klin Farmakol. 1994 Mar-Apr;57(2):57-60.
9
Analysis of drug interactions in combined drug therapy by reflection method.采用反射法分析联合药物治疗中的药物相互作用。
Acta Pharmacol Sin. 2000 Feb;21(2):183-7.
10
First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity.使用RNA适配体技术的解毒剂控制型抗凝剂的首次人体试验：一种用于因子IXa活性可控调节的药物-解毒剂组合的1a期药效学评估。
Circulation. 2006 Dec 5;114(23):2490-7. doi: 10.1161/CIRCULATIONAHA.106.668434. Epub 2006 Nov 13.
Zotero 插件