氯代烯烃致癌性的最新研究发现。
Recent findings on the carcinogenicity of chlorinated olefins.
作者信息
Maltoni C
出版信息
Environ Health Perspect. 1977 Dec;21:1-5. doi: 10.1289/ehp.77211.
Abstract
Data are presented on factors affecting the carcinogenic effects of chlorinated olefins, such as molecular structure, concentration, length of treatment, route of administration and animal species, strain, sex, and age. The observations are based upon carcinogenicity experimental bioassays of vinyl chloride and vinylidene chloride. Early results, which appear to show that some of these factors (particularly species, strain, and sex) act by affecting the metabolism of the tested compounds, are presented, and the need for metabolic characterization of experimental animals in chemical carcinogenesis is stressed.
摘要
本文给出了有关影响氯代烯烃致癌作用的因素的数据，如分子结构、浓度、处理时间长短、给药途径以及动物的种类、品系、性别和年龄。这些观察结果基于氯乙烯和偏二氯乙烯的致癌性实验生物测定。文中给出了早期结果，这些结果似乎表明其中一些因素（特别是种类、品系和性别）通过影响受试化合物的代谢而起作用，并强调了在化学致癌作用中对实验动物进行代谢特征描述的必要性。
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