Ayim J S, Dwuma Badu D, Fiagbe N Y, Ateya A M, Slatkin D J, Knapp J E, Schiff P L
Lloydia. 1977 Nov-Dec;40(6):561-5.
Tiliacora funifera (Menispermaceae) is a woody climber of Ghana and West Africa that has been used natively as a medicinal in the treatment of numerous ailments. Chromatography of an extract of the leaves of T. funifera afforded tiliafunimine (13) whose ir, uv, nmr, and mass spectra were characteristic of a trimethoxylated phenolic iminobisbenzylisoquinoline alkaloid. Reduction of tiliafunimine with sodium borohydride afforded the dihydro-derivative (14) which upon treatment with formalin gave thalrugosine (12). The final structural assignment of tiliafunimine (13) as an iminobisbenzylisoquinoline alkaloid was made by nmr and mass spectral considerations. Other alkaloids isolated from the same extract include the bisbenzylisoquinoline bases isotetrandrine (11) and thalrugosine (12).
蒂利亚藤（防己科）是加纳和西非的一种木质藤本植物，在当地一直被用作治疗多种疾病的药物。对蒂利亚藤叶子提取物进行色谱分析得到了蒂利亚藤宁（13），其红外光谱、紫外光谱、核磁共振光谱和质谱具有三甲氧基化酚基亚氨基双苄基异喹啉生物碱的特征。用硼氢化钠还原蒂利亚藤宁得到二氢衍生物（14），该衍生物用福尔马林处理后得到thalrugosine（12）。通过核磁共振光谱和质谱分析确定了蒂利亚藤宁（13）为亚氨基双苄基异喹啉生物碱。从同一提取物中分离出的其他生物碱包括双苄基异喹啉碱异粉防己碱（11）和thalrugosine（12）。
