Vignon E, Arlot M, Meunier P, Vignon G
Nouv Presse Med. 1977 Nov 5;6(37):3397-400.
A study of three femoral heads removed from patients suffering from articular chondrocalcinosis enabled the authors to identify the lesions of the cartilage in that disorder. They are mainly represented by crystals of calcium pyrophosphate. They appear within the cartilage which is macroscopically intact and histologically normal, but their location and the related tissue phenomena in their formation remain controversial and poorly understood. They accumulate in the various layers of the non-calcified cartilage within which they appear to hollow out genuine cavities by pushing back and then destroying the intercellular matrix and surrounding chondrocytes. In spite of their at times considerable size, the accumulations of crystals are not accompanied with fissures or erosion of cartilage tissue. This good histological tolerance appears to be explained by the distribution of calcification outside of the areas bearing pressure, which is in agreement with the often asymptomatic nature of chondrocalcinosis. These calcfications appear to be able to render cartilage fragile and to lead to pseudoarthrosic arthropathy when they are abundant and spread through the entire surface of a joint.
一项对取自患有关节软骨钙质沉着症患者的三个股骨头的研究，使作者能够识别出该病症中软骨的病变情况。它们主要以焦磷酸钙晶体的形式存在。它们出现在宏观上完整且组织学上正常的软骨内，但其位置以及形成过程中相关的组织现象仍存在争议且了解甚少。它们积聚在未钙化软骨的各层中，在其中它们似乎通过推开然后破坏细胞间基质和周围软骨细胞而挖出真正的腔隙。尽管晶体聚集体有时相当大，但软骨组织并未出现裂隙或侵蚀现象。这种良好的组织学耐受性似乎可以通过钙化分布在承受压力区域之外来解释，这与软骨钙质沉着症通常无症状的性质相符。当这些钙化丰富并扩散至关节整个表面时，似乎会使软骨变得脆弱并导致假关节性关节病。
