甲胎蛋白与雌激素代谢。I. ——甲胎蛋白对大鼠肝脏微粒体体外类固醇代谢的影响。
Alpha-foetoprotein and oestrogen metabolism. I. -Influence of alpha-foetoprotein on the metabolism of steroids by rat liver microsomes in vitro.
作者信息
Aussel C, Masseyeff R
出版信息
Biochimie. 1976;58(6):737-41. doi: 10.1016/s0300-9084(76)80399-9.
PMID:60142
Abstract
Rat alpha-foetoprotein (AFP) was shown to inhibit the formation of water soluble metabolities of oestrone and oestradiol by incubation with microsomes from rat liver in the presence of NADPH. The results support the proposal that in young animals the low activity of enzymes responsible of oestradiol metabolism may be due in part to the presence of AFP and not only to the low level of these enzymes.
摘要
通过在NADPH存在的情况下与大鼠肝脏微粒体一起孵育，发现大鼠甲胎蛋白（AFP）可抑制雌酮和雌二醇水溶性代谢物的形成。这些结果支持了这样的提议，即在幼龄动物中，负责雌二醇代谢的酶活性较低可能部分归因于AFP的存在，而不仅仅是这些酶的水平较低。
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