单次注射菊粉测定未经治疗的原发性高血压男性的细胞外液量。

Extracellular fluid volume determined by a single injection of inulin in men with untreated essential hypertension.

作者信息

Poulsen H L, Jensen H A, Parving H H

出版信息

Scand J Clin Lab Invest. 1977 Dec;37(8):691-6. doi: 10.1080/00365517709101850.

Abstract

The extracellular volume (ECV) and plasma volume (PV) were determined simultaneously in nine men with untreated essential hypertension and in nine healthy matched control subjects, using a single injection of inulin and of 131I-labelled human serum albumin, respectively. The average mean arterial blood pressure in the hypertensive group was 178/118 mmHg. ECV was nearly the same in the two groups, viz. 151 ml/kg body weight (SD 17) in the hypertensive group compared to 147 ml/kg (SD 16) in the control group. The corresponding figures for PV were 38.2 ml/kg body weight (SD 4.7) and 43.7 ml/kg (SD 7.9) respectively (P less than 0.1). The calculated interstitial fluid volume (IV) was 113 ml/kg (SD 16) and 103 ml/kg (SD 10) (P less than 0.2). The PV/IV ratio was significantly lower (P less than 0.02) in the hypertensive group (0.34, SD 0.06) than in the normal group (0.42, SD 0.06). The difference might suggest increased transcapillary water filtration in hypertension.

摘要

分别单次注射菊粉和¹³¹I标记的人血清白蛋白，同时测定了9例未经治疗的原发性高血压男性患者及9例相匹配的健康对照者的细胞外液量（ECV）和血浆量（PV）。高血压组的平均动脉血压为178/118 mmHg。两组的ECV几乎相同，高血压组为151 ml/kg体重（标准差17），而对照组为147 ml/kg（标准差16）。PV的相应数值分别为38.2 ml/kg体重（标准差4.7）和43.7 ml/kg（标准差7.9）（P<0.1）。计算得出的组织间液量（IV）分别为113 ml/kg（标准差16）和103 ml/kg（标准差10）（P<0.2）。高血压组的PV/IV比值（0.34，标准差0.06）显著低于正常组（0.42，标准差0.06）（P<0.02）。这种差异可能提示高血压时毛细血管滤过增加。