Hori M, Fisher J M, Rabinovitz M
Science. 1967 Jan 6;155(3758):83-4. doi: 10.1126/science.155.3758.83.
Of several amino acids essential for optimum hemoglobin synthesis by the rabbit reticulocyte, only omission of tryptophan results in polyribosome disaggregation. This disaggregation is prevented by the omission of both tryptophan and an amino acid that is relatively more essential than tryptophan for hemoglobin synthesis. Since tryptophan is located only near the amino-terminal ends of both chains of rabbit globin, the results indicate that single ribosomes and those in polyribosomes are in a dynamic state in the intact cell.
在兔网织红细胞合成最佳血红蛋白所需的几种氨基酸中，只有色氨酸的缺失会导致多核糖体解聚。色氨酸和一种对血红蛋白合成比色氨酸相对更必需的氨基酸同时缺失时，可防止这种解聚。由于色氨酸仅位于兔球蛋白两条链的氨基末端附近，结果表明完整细胞中的单个核糖体和多核糖体中的核糖体处于动态状态。
