利福霉素衍生物单独及与两性霉素B联合使用对荚膜组织胞浆菌的作用。
Effects of rifamycin derivatives, alone and in combination with amphotericin B, against Histoplasma capsulatum.
作者信息
Kobayashi G S, Cheung S S, Schlessinger D, Medoff G
出版信息
Antimicrob Agents Chemother. 1974 Jan;5(1):16-8. doi: 10.1128/AAC.5.1.16.
Abstract
Several derivatives of rifamycin SV inhibited ribonucleic acid synthesis and decreased the viability of Histoplasma capsulatum. Both of these effects were enhanced by low concentrations of amphotericin B. The relative potency of the different rifamycin derivatives against H. capsulatum, when used in combination with amphotericin B or alone, was the same as that reported for the inhibition of the reverse transcriptase of ribonucleic acid tumor viruses.
摘要
利福霉素SV的几种衍生物抑制核糖核酸合成，并降低荚膜组织胞浆菌的活力。低浓度的两性霉素B可增强这两种作用。不同利福霉素衍生物与两性霉素B联合使用或单独使用时，对荚膜组织胞浆菌的相对效力与报道的对核糖核酸肿瘤病毒逆转录酶抑制作用的效力相同。
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Potentiation of the antifungal effects of antibiotics by amphotericin B.两性霉素B增强抗生素的抗真菌作用。
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