Miyamoto K, Matsumoto S
J Exp Med. 1967 Mar 1;125(3):447-56. doi: 10.1084/jem.125.3.447.
Comparative neuropathology of Ammon's horn caused by both the street and fixed rabies infection was studied by combined light and electron microscopy. Neurons containing Negri bodies appeared comparatively little damaged. In striking contrast, in the case of fixed virus infection, neurons showed the following variety of degeneration. Lightly damaged neurons showed an increase in the number of small vesicles throughout the cytoplasm. A considerable number of lysosomes were also encountered within these nerve cells. Severe necrotic alteration involving the nucleus as well as the cytoplasm was found in the nerve cell band. The characteristic homogeneous foci (matrices) were discernible within these neurons. It appears that the matrix is morphologically identical with the ground substance of the Negri body, though its size is smaller than that of the Negri body. This evidence suggests a possibility that fixed virus injures neurons so extensively that they cannot bring about the full development of the characteristic matrix of the Negri body recognizable by the light microscope. Selective vulnerability was demonstrated among different groups of neurons in respect of cytopathogenesis of both street and fixed virus infection.
采用光学显微镜和电子显微镜相结合的方法，对街毒狂犬病感染和固定毒狂犬病感染所致海马角的比较神经病理学进行了研究。含有内基小体的神经元受损相对较轻。与之形成鲜明对比的是，在固定毒感染的情况下，神经元出现了以下多种变性。轻度受损的神经元在整个细胞质中可见小泡数量增加。在这些神经细胞内还发现了大量溶酶体。在神经细胞带中发现了涉及细胞核和细胞质的严重坏死性改变。在这些神经元内可辨认出特征性的均质病灶（基质）。尽管基质的大小比内基小体小，但在形态上似乎与内基小体的基质相同。这一证据提示，固定毒对神经元的损伤如此广泛，以至于它们无法使光镜下可识别的内基小体特征性基质充分发育。在街毒和固定毒感染的细胞病变发生方面，不同组别的神经元表现出选择性易损性。
