Department of Toxicology, Faculty of Pharmacy, Medical University of Gdańsk, 107 Hallera Street, 80-416 Gdańsk, Poland.
Int J Environ Res Public Health. 2022 Feb 9;19(4):1935. doi: 10.3390/ijerph19041935.
Humans are exposed to numerous potentially harmful chemicals throughout their lifetime. Although many studies have addressed this issue, the data on chronic exposure is still lacking. Hence, there is a growing interest in methods and tools allowing to longitudinally track personal exposure to multiple chemicals via different routes. Since the seminal work, silicone wristbands (WBs) have been increasingly used to facilitate human exposure assessment, as using WBs as a wearable sampler offers new insights into measuring chemical risks involved in many ambient and occupational scenarios. However, the literature lacks a detailed overview regarding methodologies being used; a comprehensive comparison with other approaches of personal exposure assessment is needed as well. Therefore, the aim of this review is fourfold. First, we summarize hitherto conducted research that employed silicone WBs as personal passive samplers. Second, all pre-analytical and analytical steps used to obtain exposure data are discussed. Third, we compare main characteristics of WBs with key features of selected matrices used in exposure assessment, namely urine, blood, hand wipes, active air sampling, and settled dust. Finally, we discuss future needs of research employing silicone WBs. Our work shows a variety of possibilities, advantages, and caveats associated with employment of silicone WBs as personal passive samplers. Although further research is necessary, silicone WBs have already been proven valuable as a tool for longitudinal assessment of personal exposure.
人的一生会接触到大量潜在的有害物质。尽管许多研究已经解决了这个问题，但关于慢性暴露的数据仍然缺乏。因此，人们越来越关注允许通过不同途径对个人的多种化学物质暴露进行纵向追踪的方法和工具。自开创性工作以来，硅树脂腕带（WBs）越来越多地被用于促进人类暴露评估，因为将 WBs 用作可穿戴采样器为测量许多环境和职业场景中的化学风险提供了新的见解。然而，文献中缺乏关于所使用方法的详细概述；需要与个人暴露评估的其他方法进行全面比较。因此，本综述的目的有四个。首先，我们总结了迄今为止使用硅树脂 WB 作为个人被动采样器进行的研究。其次，讨论了获得暴露数据的所有预分析和分析步骤。第三，我们将 WB 的主要特征与暴露评估中使用的选定基质（尿液、血液、手擦拭物、主动空气采样和沉降灰尘）的关键特征进行比较。最后，我们讨论了未来使用硅树脂 WB 进行研究的需求。我们的工作展示了作为个人被动采样器使用硅树脂 WB 所具有的各种可能性、优势和注意事项。尽管需要进一步研究，但硅树脂 WB 已经被证明是一种用于个人暴露纵向评估的有价值的工具。
