抗原刺激的淋巴结细胞的电泳迁移率。
Electrophoretic mobilities of antigen-stimulated lymph node cells.
作者信息
Sundaram K, Phondke G P, Ambrose E J
出版信息
Immunology. 1967 Jan;12(1):21-6.
The effect of immunization against a bacterial antigen on electrophoretic mobility of lymph node cells has been studied. Incubation of non-stimulated lymph node cells with antigens altered their electrophoretic mobility. However, on washing the antigen away, the original mobility was regained. Antigen-stimulated lymph node cells had a lower electrophoretic mobility. It was further irreversibly reduced on incubation with the same antigen. This suggests the possibility of formation of firm antigen—antibody complexes at the cell surface. Implications of these findings and feasibility of using the technique of cell electrophoresis for the study of immune response at the cellular level is discussed.
已经研究了针对细菌抗原的免疫接种对淋巴结细胞电泳迁移率的影响。将未受刺激的淋巴结细胞与抗原一起孵育会改变其电泳迁移率。然而，洗去抗原后，又恢复了原来的迁移率。抗原刺激的淋巴结细胞具有较低的电泳迁移率。用相同抗原孵育后，其电泳迁移率进一步不可逆地降低。这表明在细胞表面可能形成了牢固的抗原-抗体复合物。讨论了这些发现的意义以及使用细胞电泳技术在细胞水平研究免疫反应的可行性。
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