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红细胞中的谷胱甘肽还原酶：与痛风相关的变体

Glutathione reductase in red blood cells: variant associated with gout.

作者信息

Long W K

出版信息

Science. 1967 Feb 10;155(3763):712-3. doi: 10.1126/science.155.3763.712.

DOI:10.1126/science.155.3763.712
PMID:6017801
Abstract

A variant of red cell gluta thione reductase, characterized by greater electrophoretic mobility, in creased enzyme activity per unit of hemoglobin, and an autosomal mode of inheritance, has been found in Negro populations. There appears to be an association of this variant with primary gout.

摘要

在黑人人群中发现了一种红细胞谷胱甘肽还原酶变体，其特征为电泳迁移率更高、每单位血红蛋白的酶活性增加以及常染色体遗传模式。这种变体似乎与原发性痛风有关。

相似文献

1
Glutathione reductase in red blood cells: variant associated with gout.红细胞中的谷胱甘肽还原酶：与痛风相关的变体
Science. 1967 Feb 10;155(3763):712-3. doi: 10.1126/science.155.3763.712.
2
Effect of treatment on erythrocyte phosphoribosyl pyrophosphate synthetase and glutathione reductase activity in patients with primary gout.治疗对原发性痛风患者红细胞磷酸核糖焦磷酸合成酶和谷胱甘肽还原酶活性的影响。
Ann Rheum Dis. 1986 Nov;45(11):941-4. doi: 10.1136/ard.45.11.941.
3
Phosphoribosyl pyrophosphate synthetase and glutathione reductase in erythrocytes from hyperuricaemic and gout patients.高尿酸血症和痛风患者红细胞中的磷酸核糖焦磷酸合成酶和谷胱甘肽还原酶
Clin Chim Acta. 1982 Dec 23;126(3):217-26. doi: 10.1016/0009-8981(82)90295-9.
4
Electrophoresis of glutathione reductase from human red blood cells.人红细胞谷胱甘肽还原酶的电泳分析
Biochim Biophys Acta. 1968 Mar 25;151(3):686-8. doi: 10.1016/0005-2744(68)90018-1.
5
ACP1GUA-1--a low-activity variant of human erythrocyte acid phosphatase: association with increased glutathione reductase activity.ACP1GUA - 1——人类红细胞酸性磷酸酶的一种低活性变体：与谷胱甘肽还原酶活性增加相关
Am J Hum Genet. 1982 May;34(3):425-33.
6
Erythrocyte glutathione reductase in gout and in glucose-6-phosphate dehydrogenase deficiency.痛风及葡萄糖-6-磷酸脱氢酶缺乏症中的红细胞谷胱甘肽还原酶
Monogr Hum Genet. 1978;9:16-9. doi: 10.1159/000401604.
7
Age-related changes of glutathione content, glutathione reductase and glutathione peroxidase activity of human erythrocytes.人红细胞中谷胱甘肽含量、谷胱甘肽还原酶及谷胱甘肽过氧化物酶活性的年龄相关性变化。
Braz J Med Biol Res. 1991;24(5):449-54.
8
[Glutathione content and glutathione reducing enzymes in red blood cells of different age (author's transl)].不同年龄红细胞中的谷胱甘肽含量及谷胱甘肽还原酶（作者译）
Klin Wochenschr. 1974 Feb 15;52(4):179-84. doi: 10.1007/BF01614394.
9
Glutathione reductase of human erythrocytes. Purification and properties.人类红细胞谷胱甘肽还原酶。纯化及特性
Scand J Clin Lab Invest Suppl. 1967;96:1-67.
10
[Research on the relations between age and characteristics of the glutathione reductase of human erythrocytes].[关于年龄与人类红细胞谷胱甘肽还原酶特性之间关系的研究]
Boll Soc Ital Biol Sper. 1970 Sep 30;46(18):743-7.

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Alterations in the prooxidant and antioxidant status of human leukemic T-lymphocyte MOLT4 cells treated with potassium chromate.用铬酸钾处理的人白血病T淋巴细胞MOLT4细胞的促氧化剂和抗氧化剂状态的改变。
Mol Cell Biochem. 1995 Jan 12;142(1):61-70. doi: 10.1007/BF00928914.
2
Kidney stones.肾结石
West J Med. 1980 Apr;132(4):313-32.
3
Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies.黄素化合物对谷胱甘肽还原酶活性的影响：体内和体外研究
J Clin Invest. 1969 Oct;48(10):1957-66. doi: 10.1172/JCI106162.
4
A general model to account for enzyme variation in natural populations.一个解释自然种群中酶变异的通用模型。
Genetics. 1974 Apr;76(4):837-48. doi: 10.1093/genetics/76.4.837.
5
[Properties of erythrocyte glutathione reductase from normal and enzyme-deficient subjects (author's transl)].[正常人和酶缺乏受试者红细胞谷胱甘肽还原酶的特性（作者译）]
Klin Wochenschr. 1973 Dec 15;51(24):1177-84. doi: 10.1007/BF01468553.
6
Molecular variation in relation to purine metabolism.与嘌呤代谢相关的分子变异
J Clin Pathol Suppl (R Coll Pathol). 1974;8:48-63.
7
The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.给予（15N）甘氨酸后尿酸中15N的分子内分布动力学。对原发性痛风中尿酸N-（3+9）优先标记意义的重新评估。
J Clin Invest. 1973 Oct;52(10):2468-85. doi: 10.1172/JCI107438.
8
Effect of treatment on erythrocyte phosphoribosyl pyrophosphate synthetase and glutathione reductase activity in patients with primary gout.治疗对原发性痛风患者红细胞磷酸核糖焦磷酸合成酶和谷胱甘肽还原酶活性的影响。
Ann Rheum Dis. 1986 Nov;45(11):941-4. doi: 10.1136/ard.45.11.941.
9
Polymorphism and linkage of glutathione reductase in Mus musculus.小家鼠谷胱甘肽还原酶的多态性与连锁关系
Biochem Genet. 1975 Jun;13(5-6):323-9. doi: 10.1007/BF00485817.
10
Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation.球形红细胞增多症定位于8号或12号染色体及一个球形红细胞增多症与相互易位家系的报告
Am J Hum Genet. 1975 Sep;27(5):586-94.