小鼠补体：性激素和去势对两种晚期作用成分的影响。
Mouse complement: the effect of sex hormones and castration on two of the late-acting components.
作者信息
Churchill W H, Weintraub R M, Borsos T, Rapp H J
出版信息
J Exp Med. 1967 Apr 1;125(4):657-72. doi: 10.1084/jem.125.4.657.
Abstract
The titer of late-acting complement components in sera from male mice is 8-10 times higher than the titer of sera from female mice. Using assays developed to measure the serum content of two of the late-acting components, we have shown that this difference is due to the effect of androgen and estrogen on these two late-acting complement components. These two components have been tentatively identified as C'5 and C'6. Androgen and estrogen have greater effect on C'6 than on C'5. The possibility has not been excluded that still other of the late-acting complement components are affected by androgens and estrogens. The course of homograft rejection was unchanged in mice deficient in C'5 and C'6.
摘要
雄性小鼠血清中晚期补体成分的效价高于雌性小鼠血清效价的8至10倍。通过开发的检测方法来测量两种晚期补体成分的血清含量，我们发现这种差异是由于雄激素和雌激素对这两种晚期补体成分的作用所致。这两种成分初步确定为C'5和C'6。雄激素和雌激素对C'6的作用比对C'5的作用更大。尚未排除其他晚期补体成分也受雄激素和雌激素影响的可能性。C'5和C'6缺陷的小鼠同种异体移植排斥过程未发生改变。
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本文引用的文献
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Mouse complement: influence of sex hormones on its activity.鼠补体：性激素对其活性的影响。
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Steroids and serum complement in mice: influence of hydrocortisone, diethylstilbestrol, and testosterone.类固醇和血清补体在小鼠中的作用：氢化可的松、己烯雌酚和睾酮的影响。
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DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT.抗原MUB1的分布、遗传特性及其与溶血补体的关系
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