Rother K, Rother U, Müller-Eberhard H J, Nilsson J R
J Exp Med. 1966 Oct 1;124(4):773-85. doi: 10.1084/jem.124.4.773.
A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.
已证明，一种患有遗传性补体缺陷的兔种缺乏溶血补体系统的第六成分。现已精心制定出一种从正常兔血清中部分纯化该成分的方法。将部分纯化的兔C'6注入C'6缺陷动物体内后，获得了一种能特异性抑制C'6溶血活性的抗体。这些数据表明，C'6缺陷血清要么缺乏C'6分子，要么含有化学修饰且无活性形式的C'6分子。
