氨基酸对大鼠肝切片摄取铜的影响。
The influence of amino acids on copper uptake by rat liver slices.
作者信息
Harris D I, Sass-Kortsak A
出版信息
J Clin Invest. 1967 Apr;46(4):659-67. doi: 10.1172/JCI105567.
Abstract
Addition of physiological concentrations of 20 l-amino acids to the incubation medium facilitates the uptake of copper by liver slices. This effect can be observed in a wide range of initial concentrations of copper in the medium, including the low physiological concentrations. The uptake of copper was not influenced by the addition of sodium lactate or d-glucose to the incubation media. The facilitation of copper uptake by amino acids is abolished under anaerobic conditions. It is not affected by the presence of 2,4-dinitrophenol. The type of transport and its exact mechanism have not been established, but this type of transport does not fulfill the criteria for classification as simple diffusion.
摘要
向孵育培养基中添加生理浓度的20种L-氨基酸可促进肝切片对铜的摄取。在培养基中广泛的初始铜浓度范围内，包括低生理浓度，都能观察到这种效应。向孵育培养基中添加乳酸钠或D-葡萄糖不会影响铜的摄取。在厌氧条件下，氨基酸对铜摄取的促进作用消失。它不受2,4-二硝基苯酚存在的影响。转运类型及其确切机制尚未确定，但这种转运类型不符合简单扩散分类的标准。
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