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1
A comparative study of in vitro and in vivo interaction of D-penicillamine and triethylenetetramine with copper.D-青霉胺和三亚乙基四胺与铜的体外和体内相互作用的比较研究。
Proc R Soc Med. 1977;70 Suppl 3(Suppl 3):13-8. doi: 10.1177/00359157770700S307.
2
Evaluation of Cuprimine and Syprine for decorporation of (60)Co and (210)Po.评估青霉胺和曲恩汀对（60）钴和（210）钋的促排作用。
Health Phys. 2010 Mar;98(3):471-9. doi: 10.1097/HP.0b013e3181bcdf4f.
3
The cupruretic effect of two chelators following copper loading in sheep.绵羊铜负荷后两种螯合剂的促铜排泄作用
Vet Hum Toxicol. 1993 Oct;35(5):409-13.
4
Computer models of metal ion-low molecular weight equilibria in plasma and the influence of D-penicillamine, triethylenetetramine and EDTA.血浆中金属离子与低分子量物质平衡的计算机模型以及青霉胺、三乙烯四胺和乙二胺四乙酸的影响。
Proc R Soc Med. 1977;70 Suppl 3(Suppl 3):19-23. doi: 10.1177/00359157770700S308.
5
An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation.关于铜催化D-青霉胺氧化及随后过氧化氢生成的研究。
J Inorg Biochem. 2007 Apr;101(4):594-602. doi: 10.1016/j.jinorgbio.2006.12.007. Epub 2006 Dec 20.
6
Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines.新型快速铜螯合评估方法证实，与曲恩汀和 8-羟基喹啉相比，D-青霉胺与铜的亲和力较低。
J Inorg Biochem. 2013 Jun;123:80-7. doi: 10.1016/j.jinorgbio.2013.02.011. Epub 2013 Mar 19.
7
Evaluation of the efficacy of d-penicillamine and trientine as copper chelators using an in vitro technique involving ovine red blood cells.使用涉及绵羊红细胞的体外技术评估d-青霉胺和曲恩汀作为铜螯合剂的疗效。
Onderstepoort J Vet Res. 1992 Sep;59(3):191-5.
8
The interactions of penicillamine with copper in vivo and the effect on hepatic metallothionein levels and copper/zinc distribution: the implications for Wilson's disease and arthritis therapy.青霉胺在体内与铜的相互作用及其对肝脏金属硫蛋白水平和铜/锌分布的影响：对威尔逊病和关节炎治疗的意义。
J Lab Clin Med. 1992 Jun;119(6):744-50.
9
Enhanced intracellular delivery of the reactive oxygen species (ROS)-generating copper chelator D-penicillamine via a novel gelatin--D-penicillamine conjugate.通过新型明胶 - D - 青霉胺共轭物增强产生活性氧（ROS）的铜螯合剂D - 青霉胺的细胞内递送。
Bioconjug Chem. 2008 Jul;19(7):1382-8. doi: 10.1021/bc800042s. Epub 2008 Jun 21.
10
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.螯合与嵌入：用于治疗阿尔茨海默病的化合物中的互补特性
J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.

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1
Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases.植物来源的螯合剂和离子载体作为代谢疾病的潜在治疗方法。
Chem Soc Rev. 2023 Jun 6;52(11):3927-3945. doi: 10.1039/d3cs00167a.
2
Chelation Combination-A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper?螯合联合策略——减轻锰、铁和铜的神经毒性？
Biomolecules. 2022 Nov 18;12(11):1713. doi: 10.3390/biom12111713.
3
Switching Pharmacological Treatment in Wilson Disease: Case Report and Recommendations.Wilson 病的药物转换治疗：病例报告与建议。
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709619896876. doi: 10.1177/2324709619896876.
4
Current anti-copper therapies in management of Wilson disease.目前用于威尔逊病治疗的抗铜疗法。
Ann Transl Med. 2019 Apr;7(Suppl 2):S69. doi: 10.21037/atm.2019.02.48.
5
Wilson's disease: A review of what we have learned.威尔逊氏病：我们所了解内容的综述。
World J Hepatol. 2015 Dec 18;7(29):2859-70. doi: 10.4254/wjh.v7.i29.2859.
6
Stimulation of urinary copper excretion by trientine((R)) in nickel-sensitive patients.曲恩汀((R))刺激镍敏感患者的尿铜排泄。
Biol Trace Elem Res. 1987 Oct;14(1-2):65-77. doi: 10.1007/BF02795597.
7
Cellular responses to the metal-binding properties of metformin.细胞对二甲双胍金属结合特性的反应。
Diabetes. 2012 Jun;61(6):1423-33. doi: 10.2337/db11-0961. Epub 2012 Apr 9.
8
A comparison of therapies which may influence trace metals in rheumatoid arthritis.可能影响类风湿关节炎中微量元素的疗法比较。
Clin Rheumatol. 1984 Dec;3(4):451-7. doi: 10.1007/BF02031267.
9
The effect of drugs on serum histidine levels in rheumatoid arthritis.药物对类风湿关节炎患者血清组氨酸水平的影响。
Rheumatol Int. 1983;3(4):145-9. doi: 10.1007/BF00541592.
10
Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. A change in the differentiation commitment.成年大鼠胰腺导管周围和小导管上皮细胞在胰腺肝细胞谱系中的作用。分化承诺的改变。
Am J Pathol. 1989 May;134(5):1069-86.

本文引用的文献

1
Penicillamine, a new oral therapy for Wilson's disease.青霉胺，一种治疗威尔逊氏病的新型口服疗法。
Am J Med. 1956 Oct;21(4):487-95. doi: 10.1016/0002-9343(56)90066-3.
2
Separation of Cu(II)-amino acid complexes and evidence for the existence of histidine-Cu(II)-glutamine and histidine-Cu(II)-serume complexes at physiological pH.生理pH条件下Cu（II）-氨基酸配合物的分离以及组氨酸-Cu（II）-谷氨酰胺和组氨酸-Cu（II）-血清配合物存在的证据。
Can J Biochem. 1967 Dec;45(12):2046-9. doi: 10.1139/o67-238.
3
The influence of amino acids on copper uptake by rat liver slices.氨基酸对大鼠肝切片摄取铜的影响。
J Clin Invest. 1967 Apr;46(4):659-67. doi: 10.1172/JCI105567.
4
A peptide molecule mimicking the copper(II) transport site of human serum albumin. A comparative study between the synthetic site and albumin.一种模拟人血清白蛋白铜（II）转运位点的肽分子。合成位点与白蛋白之间的比较研究。
J Biol Chem. 1974 Sep 25;249(18):5878-84.
5
Preparation of triethylenetetramine dihydrochloride for the treatment of Wilson's disease.用于治疗威尔逊氏病的二盐酸三乙烯四胺的制备。
Lancet. 1972 Apr 15;1(7755):853. doi: 10.1016/s0140-6736(72)90845-8.
6
Properties of the red - violet complex of copper and penicillamine and further insight into its formation reaction.铜与青霉胺的红紫色络合物的性质及其形成反应的进一步深入研究
Bioinorg Chem. 1975 Jan;4(2):163-75. doi: 10.1016/s0006-3061(00)81025-x.

A comparative study of in vitro and in vivo interaction of D-penicillamine and triethylenetetramine with copper.

作者信息

Sarkar B, Sass-Kortsak A, Clarke R, Laurie S H, Wei P

机构信息

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

Proc R Soc Med. 1977;70 Suppl 3(Suppl 3):13-8. doi: 10.1177/00359157770700S307.

DOI:10.1177/00359157770700S307
PMID:122660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1543606/
Abstract
摘要