Barinskiĭ I F, Zaĭtseva N S, Krichevskaia E I, Slepova O S, Vinogradova V I
Vopr Virusol. 1977 Nov-Dec(6):670-5.
Chronic herpes infection has been reproduced in rabbits in which the mechanism of the effect of inactivated herpes vaccine was studied. Vaccination did not affect the level of humoral antibody in chronically infected animals and did not enhance the capacity of their leucocytes for interferon production in vitro. A course of vaccination enhanced cellular immunity responses as manifested in an increase in the level of blast transformation to specific antigen up to 30 percent one week after termination of the course. One month later the reaction became negative indicating the necessity of multiple vaccination courses for prevention of relapses of herpetic eye disease.
在兔子身上再现了慢性疱疹感染，以此研究灭活疱疹疫苗的作用机制。接种疫苗对慢性感染动物的体液抗体水平没有影响，也没有提高其白细胞在体外产生干扰素的能力。一个疗程的接种增强了细胞免疫反应，表现为在疗程结束后一周，对特定抗原的母细胞转化水平提高了30%。一个月后反应转为阴性，这表明为预防疱疹性眼病复发需要进行多个疗程的接种。
