脐动脉置管新生儿预防性使用抗生素：137例患者的前瞻性研究
Prophylactic antibiotics in neonates with umbilical artery catheter placement: a prospective study of 137 patients.
作者信息
Cowett R M, Peter G, Hakanson D O, Stern L, Oh W
出版信息
Yale J Biol Med. 1977 Sep-Oct;50(5):457-63.
To analyze the risk of cannula sepsis from indwelling umbilical arterial catheters and the indication for prophylactic antibiotics, 137 catheterized neonates with respiratory distress were prospectively placed into either antibiotic-treated (penicillin 50,000U/kg/day and kanamycin 15 mg./kg./day) or non-treated groups. Although bacteria were frequently isolated from blood and catheter tip cultures obtained upon removal of the catheter, especially among non-antibiotic treated infants, these isolates were predominantly non-pathogens and probably skin flora. Corresponding peripheral blood cultures were usually sterile. No cases of cannula-associated sepsis occurred among treated and non-treated newborns. The risk of bacteriologically proven sepsis resulting from an indwelling umbilical artery catheter appears insufficient to justify prophylactic antibiotics.
为分析留置脐动脉导管引起套管败血症的风险及预防性使用抗生素的指征，对137例患有呼吸窘迫的导管插入术新生儿进行前瞻性研究，将其分为抗生素治疗组（青霉素50,000U/kg/天和卡那霉素15mg/kg/天）和非治疗组。尽管在拔除导管时从血液和导管尖端培养物中经常分离出细菌，尤其是在未接受抗生素治疗的婴儿中，但这些分离菌主要是非病原体，可能是皮肤菌群。相应的外周血培养通常无菌。治疗组和非治疗组的新生儿均未发生与套管相关的败血症。留置脐动脉导管导致经细菌学证实的败血症的风险似乎不足以证明预防性使用抗生素是合理的。
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