人类睡眠与5-羟色氨酸。重复高剂量及与苄丝肼联合使用（RO.04.4602）的效果。

Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602).

作者信息

Autret A, Minz M, Bussel B, Cathala H P, Castaigne P

出版信息

Electroencephalogr Clin Neurophysiol. 1976 Oct;41(4):408-13. doi: 10.1016/0013-4694(76)90103-6.

Abstract

On account of the conflicting data concerning the action of 5-HTP on human sleep, repeated high doses were administered to three healthy subjects. The paradoxical sleep time and percentage tend to show a decrease during the 2nd week of treatment, followed by a rebound effect after the end of the treatment. In two subjects who initially had a small amount of slow wave sleep (SWS), the treatment induced an increase in SWS that persisted after the end of the treatment. Similar results were obtained after administration of 5-HTP together with RO.04.4602.

摘要

由于关于5-羟色氨酸对人类睡眠作用的数据相互矛盾，对三名健康受试者给予了重复高剂量的5-羟色氨酸。在治疗的第二周，异相睡眠时间和百分比往往会下降，治疗结束后会出现反弹效应。在最初慢波睡眠（SWS）量较少的两名受试者中，治疗导致SWS增加，且在治疗结束后仍持续存在。给予5-羟色氨酸与RO.04.4602后也获得了类似结果。