人类前列腺雄激素。

Androgen of the human prostate.

作者信息

Farnsworth W E, Brown J R

出版信息

Endocr Res Commun. 1976;3(2):105-17. doi: 10.3109/07435807609052926.

Abstract

The relationship between the concentrations of total and apparent free testosterone in the plasma and the levels of testosterone (T), dihydrotestosterone (DHT) and 5 alpha-androstan-3-alpha, 17 beta-diol (DIOL) in 13 benign hypertrophic and 6 carcinomatous prostates was studied. The androgen concentration within both types of glands was nearly 4-fold that in the blood but bore no direct relationship to the blood level. About 75% of the androgen in the tissue was DHT. The most striking finding was that, in spite of a 25.5% less concentrated pool of apparent free testosterone in the blood, the level of T and its metabolites in the cancer tissue was 29% above that in the samples of benign hypertrophic prostate.

摘要

研究了13例良性前列腺增生和6例前列腺癌患者血浆中总睾酮和表观游离睾酮浓度与睾酮（T）、双氢睾酮（DHT）及5α-雄甾烷-3α，17β-二醇（DIOL）水平之间的关系。两种类型腺体中的雄激素浓度几乎是血液中的4倍，但与血液水平无直接关系。组织中约75%的雄激素为DHT。最显著的发现是，尽管血液中表观游离睾酮的浓度池低25.5%，但癌组织中T及其代谢产物的水平比良性前列腺增生样本中的水平高29%。