Gee J B, Packer B S, Millen J E, Robin E D
J Clin Invest. 1967 Jun;46(6):945-52. doi: 10.1172/JCI105600.
Previously reported changes in static lung volumes during pregnancy have been confirmed. Measurements of lung compliance (C(L)) and total pulmonary resistance (R(L)) were made in 10 women in the last trimester of pregnancy and 2 months postpartum, employing an esophageal balloon and recording spirometer. C(L) was unaffected by pregnancy, but R(L) was 50% below normal during pregnancy. Measurements of airway conductance (C(A)) were made, employing the constant pressure body plethysmograph on 14 nonpregnant and 13 pregnant women. Specific airway conductance was increased during pregnancy. Serial measurements of C(A) indicated a progressive increase beginning at about 6 months of gestation and a return to normal by 2 months postpartum. The mechanism of the increased C(A) during pregnancy is not known. It may be related to changes in bronchial smooth muscle tone and conceivably explains the tolerance of certain patients with lung resections to pregnancy.
先前报道的孕期静态肺容量变化已得到证实。使用食管气囊和记录式肺活量计，对10名妊娠晚期妇女和产后2个月的妇女进行了肺顺应性（C(L)）和总肺阻力（R(L)）测量。C(L)不受妊娠影响，但R(L)在孕期低于正常水平50%。使用恒压体容积描记器对14名非妊娠妇女和13名妊娠妇女进行了气道传导率（C(A)）测量。孕期比气道传导率增加。C(A)的系列测量表明，从妊娠约6个月开始逐渐增加，产后2个月恢复正常。孕期C(A)增加的机制尚不清楚。它可能与支气管平滑肌张力的变化有关，并且可以解释某些肺切除患者对妊娠的耐受性。
