中性粒细胞从L-精氨酸合成一氧化氮。释放并与超氧阴离子相互作用。
Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.
作者信息
McCall T B, Boughton-Smith N K, Palmer R M, Whittle B J, Moncada S
机构信息
Wellcome Research Laboratories, Kent, U.K.
出版信息
Biochem J. 1989 Jul 1;261(1):293-6. doi: 10.1042/bj2610293.
Abstract
Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.
摘要
受刺激的大鼠腹膜中性粒细胞释放一种具有一氧化氮药理学特性的血小板抑制因子。这种释放受到N-甲基-L-精氨酸和L-刀豆氨酸的抑制，表明其发生机制与血管内皮细胞和巨噬细胞中的机制相似。随着刺激程度的增加，释放的因子会因超氧阴离子的同时释放而逐渐失活。
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