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中性粒细胞从L-精氨酸合成一氧化氮。释放并与超氧阴离子相互作用。

Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.

作者信息

McCall T B, Boughton-Smith N K, Palmer R M, Whittle B J, Moncada S

机构信息

Wellcome Research Laboratories, Kent, U.K.

出版信息

Biochem J. 1989 Jul 1;261(1):293-6. doi: 10.1042/bj2610293.

DOI:10.1042/bj2610293
PMID:2549965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1138817/
Abstract

Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.

摘要

受刺激的大鼠腹膜中性粒细胞释放一种具有一氧化氮药理学特性的血小板抑制因子。这种释放受到N-甲基-L-精氨酸和L-刀豆氨酸的抑制，表明其发生机制与血管内皮细胞和巨噬细胞中的机制相似。随着刺激程度的增加，释放的因子会因超氧阴离子的同时释放而逐渐失活。

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本文引用的文献

1
Nitrate synthesis in the germfree and conventional rat.
Science. 1981 Apr 3;212(4490):56-8. doi: 10.1126/science.6451927.
2
An improved method for washing of human platelets with prostacyclin.一种用前列环素洗涤人血小板的改进方法。
Thromb Res. 1983 May 15;30(4):383-9. doi: 10.1016/0049-3848(83)90230-x.
3
Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species.花生四烯酸和脂氧合酶产物对不同物种白细胞的趋化活性。
Prostaglandins. 1980 Aug;20(2):411-8. doi: 10.1016/s0090-6980(80)80058-x.
4
Chemoattractant receptors on phagocytic cells.吞噬细胞上的化学引诱物受体。
Annu Rev Immunol. 1984;2:257-81. doi: 10.1146/annurev.iy.02.040184.001353.
5
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.一氧化氮的释放构成了内皮源性舒张因子的生物活性。
Nature. 1987;327(6122):524-6. doi: 10.1038/327524a0.
6
Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets.血小板中内皮源性舒张因子、一氧化氮和前列环素的比较药理学
Br J Pharmacol. 1987 Sep;92(1):181-7. doi: 10.1111/j.1476-5381.1987.tb11310.x.
7
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.巨噬细胞将L-精氨酸氧化为亚硝酸盐和硝酸盐：一氧化氮是中间产物。
Biochemistry. 1988 Nov 29;27(24):8706-11. doi: 10.1021/bi00424a003.
8
Vascular endothelial cells synthesize nitric oxide from L-arginine.血管内皮细胞从L-精氨酸合成一氧化氮。
Nature. 1988 Jun 16;333(6174):664-6. doi: 10.1038/333664a0.
9
Interaction of neutrophils with vascular smooth muscle: identification of a neutrophil-derived relaxing factor.中性粒细胞与血管平滑肌的相互作用：一种中性粒细胞源性舒张因子的鉴定。
J Pharmacol Exp Ther. 1988 Apr;245(1):102-11.
10
Rapid microassays of phagocytosis, bacterial killing, superoxide and hydrogen peroxide production by human neutrophils in vitro.人中性粒细胞体外吞噬作用、细菌杀伤、超氧化物和过氧化氢产生的快速微量测定法。
J Immunol Methods. 1985 Apr 8;78(1):35-47. doi: 10.1016/0022-1759(85)90327-8.