通过豚鼠中甘露醇和赤藓糖醇清除率确定的两个胆汁生成部位。
Two sites of bile formation as determined by mannitol and erythritol clearance in the guinea pig.
作者信息
Forker E L
出版信息
J Clin Invest. 1967 Jul;46(7):1189-95. doi: 10.1172/JCI105612.
Abstract
If water and inert solutes are assumed to pass from blood to bile through a fixed population of membrane pores, the changes in clearance produced by dehydrocholate suggest that osmotic filtration rather than diffusion is the predominant mode of transfer for mannitol and erythritol. Bile produced in the canaliculi is modified in the interlobular ducts by the action of secretin. If distal fluid transfer is an important determinant of the choleresis evoked by dehydrocholate, the mechanism appears to effect a net secretion or reabsorption of fluid at a rate roughly proportional to the rate of flow in the canaliculi.
摘要
如果假定水和惰性溶质通过固定数量的膜孔从血液进入胆汁，那么脱氢胆酸盐引起的清除率变化表明，甘露醇和赤藓醇的主要转运方式是渗透过滤而非扩散。胆小管中产生的胆汁在小叶间胆管中通过促胰液素的作用而发生改变。如果远端液体转运是脱氢胆酸盐引起胆汁分泌的一个重要决定因素，那么该机制似乎是以与胆小管中流速大致成比例的速率实现液体的净分泌或重吸收。
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本文引用的文献
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Polyol dehydrogenases. I. The specificity of rat-liver polyol dehydrogenase.多元醇脱氢酶。I. 大鼠肝脏多元醇脱氢酶的特异性。
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