Holtzer J D
Immunology. 1967 Jun;12(6):713-23.
In guinea-pigs a delayed type allergy against sheep erythrocytes (SE) was obtained without the presence of cytophilic antibodies. The affinity for the antigen of the reticulo-endothelial cells of such animals was studied and compared with the affinity of cells of animals with delayed type allergy and with cytophilic antibodies. Spleen cells and peritoneal leucocytes from animals with allergy and with antibodies had an increased affinity for SE as shown by increased adherence or increaed phagocytosis. This proved to be due to cytophilic antibodies. Lymph node cells also showed an increased adherence which was only partly due to cytophilic antibodies, as one group of cells showing adherence only appeared after active immunization (antibody forming cells?). The cells of animals with delayed type allergy antibodies never showed adherence or increased phagocytosis. Thus when the presence of cytophilic antibodies was definitely excluded no evidence could be obtained that reticulo-endothelial cells of animals with delayed type allergy reacted with the antigen.
在豚鼠中，在不存在嗜细胞抗体的情况下获得了针对绵羊红细胞（SE）的迟发型变态反应。研究了这类动物的网状内皮细胞对抗原的亲和力，并将其与具有迟发型变态反应和嗜细胞抗体的动物的细胞亲和力进行了比较。有变态反应和抗体的动物的脾细胞和腹腔白细胞对SE的亲和力增加，表现为黏附增加或吞噬作用增强。这被证明是由于嗜细胞抗体所致。淋巴结细胞也显示出黏附增加，这仅部分归因于嗜细胞抗体，因为一组仅表现出黏附的细胞在主动免疫后才出现（抗体形成细胞？）。有迟发型变态反应但无抗体的动物的细胞从未显示出黏附或吞噬作用增强。因此，当明确排除嗜细胞抗体的存在时，没有证据表明有迟发型变态反应的动物的网状内皮细胞与抗原发生反应。
