嗜细胞性抗体、被动皮肤过敏反应和迟发型变态反应
Cytophilic antibodies, passive cutaneous anaphylaxis and delayed type allergy.
作者信息
Holtzer J D
出版信息
Immunology. 1968 Nov;15(5):717-31.
In guinea-pigs a delayed type allergy against sheep erythrocytes (SE) or ovalbumin without detectable circulating and macrophage-cytophilic antibodies was produced by immunization with antigen—antibody complexes. In these animals skin reactions to SE were not enhanced by admixture of macrophages, neither when the macrophages had been sensitized with cytophilic antibodies , nor when the SE had been (partially) ingested within the macrophages after incubation with opsonizing antibody . Also in these animals no enhanced delayed skin reactions to SE were obtained if before the injection of the antigen the skin had been infiltrated with cytophilic antibody or passive cutaneous anaphylaxis (PCA) antibody. Thus, no enhancing effect of cytophilic antibody on delayed cutaneous hypersensitivity reactions could be obtained. Furthermore, in guinea-pigs with delayed type allergy to ovalbumin, no enhancing effect of delayed allergy on passive cutaneous anaphylaxis was observed.
在豚鼠中，通过用抗原 - 抗体复合物免疫产生了针对绵羊红细胞（SE）或卵清蛋白的迟发型过敏反应，且未检测到循环抗体和巨噬细胞嗜细胞性抗体。在这些动物中，巨噬细胞的混合并不能增强对SE的皮肤反应，无论是巨噬细胞已被嗜细胞性抗体致敏，还是SE在与调理素抗体孵育后已被（部分）吞噬于巨噬细胞内。同样在这些动物中，如果在注射抗原之前皮肤已被嗜细胞性抗体或被动皮肤过敏反应（PCA）抗体浸润，也不会获得对SE增强的迟发性皮肤反应。因此，未观察到嗜细胞性抗体对迟发性皮肤过敏反应有增强作用。此外，在对卵清蛋白有迟发型过敏反应的豚鼠中，未观察到迟发型过敏对被动皮肤过敏反应有增强作用。
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