Jagiello G
Science. 1967 Jul 28;157(3787):453-4. doi: 10.1126/science.157.3787.453.
Streptonigrin, an antibiotic and antitumor agent, alters the chromosomes of the mouse ovum during meiosis. Agglutination of bivalents or achromatic gaps and breaks occurred in the larger pairs both in vitro and in vivo. This newly detected cytogenetic effect suggests that such agents can gain access to developing mammalian ova and destroy the normal progress of meiosis.
链黑菌素是一种抗生素和抗肿瘤剂，在减数分裂过程中会改变小鼠卵子的染色体。在体外和体内，较大的染色体对中均出现了二价体凝集或非染色质间隙及断裂。这种新检测到的细胞遗传学效应表明，这类药剂能够进入发育中的哺乳动物卵子并破坏减数分裂的正常进程。
