Koeffler H P, Golde D W
Am J Hematol. 1977;3:57-62. doi: 10.1002/ajh.2830030107.
The effect of amphotericin B on human and murine hematopoiesis was studied in vitro using assays for erythroid and myeloid colony-forming cells. Amphotericin consistently inhibited colony formation by erythroid and granulocyte-monocyte progenitor cells. Clear effects were observable at amphotericin concentrations of 1.0 microgram/ml, and concentrations of 2.0 microgram/ml caused approximately 50-60% inhibition of cloning of both murine and normal human bone marrow. These data suggest that amphotericin, in concentrations achieved in therapy, can impair hematopoiesis by a direct effect on precursor cells.
使用针对红系和髓系集落形成细胞的检测方法，在体外研究了两性霉素B对人和小鼠造血作用的影响。两性霉素持续抑制红系和粒细胞-单核细胞祖细胞的集落形成。在两性霉素浓度为1.0微克/毫升时可观察到明显效果，2.0微克/毫升的浓度可使小鼠和正常人骨髓克隆受到约50%-60%的抑制。这些数据表明，治疗中达到的两性霉素浓度可通过对前体细胞的直接作用损害造血功能。
