Fairshter R D, Glauser F L
Am J Med Sci. 1977 Sep-Oct;274(2):169-72. doi: 10.1097/00000441-197709000-00008.
A relatively high percentage of hypnotic-sedative drug-overdosed (HSDO) patients suffer post-extubation upper airway obstruction. Since early detection and treatment of these lesions is desirable, we studied 20 recently extubated (within 24 hours) as well as 11 non-intubated HSDO patients employing flow-volume loops and spirometry. Abnormalities in tests for upper airway obstruction were common in both groups but only in the four post-extubation patients with clinically suspected upper airway obstruction was an inspiratory plateau by flow volume loops found. In addition, three of these four patients had mid-VC ratios greater than 1.25. We conclude that the Inspiratory flow volume loop and the mid-VC ratio may help in detecting post-extubation upper airway obstruction in lethargic, HSDO patients.
相当高比例的催眠镇静药物过量（HSDO）患者在拔管后会出现上呼吸道梗阻。由于希望能早期发现并治疗这些病变，我们对20例近期（24小时内）拔管的以及11例未插管的HSDO患者进行了流量-容积环和肺活量测定研究。两组患者上呼吸道梗阻检查异常均很常见，但仅在4例临床怀疑有上呼吸道梗阻的拔管后患者中发现流量-容积环有吸气平台。此外，这4例患者中有3例的用力肺活量比值大于1.25。我们得出结论，吸气流量-容积环和用力肺活量比值可能有助于检测嗜睡的HSDO患者拔管后的上呼吸道梗阻。
