鸡肝中黄嘌呤脱氢酶的调节。关于肌苷、放线菌素D及其他因素作用的进一步实验。
Regulation of xanthine dehydrogenase in chick liver. Further experiments on the effects of inosine, actinomycin D and other factors.
作者信息
Della Corte E, Stirpe F
出版信息
Biochem J. 1967 Feb;102(2):520-4. doi: 10.1042/bj1020520.
Abstract
- It has been confirmed that the xanthine-dehydrogenase activity of chick liver is enhanced by starvation and by administration of inosine; the effects of these treatments are not additive. 2. Inosine has no effect when given to chicks depleted of the enzyme by feeding a low-protein diet. 3. Actinomycin D prevents the effect of inosine, but itself enhances the activity of xanthine dehydrogenase. 4. The xanthine-dehydrogenase activity is unchanged after addition of orotic acid to the diet, and is stimulated by injection of inorganic iron.
摘要
- 已经证实，饥饿和给予肌苷可增强鸡肝脏的黄嘌呤脱氢酶活性；这些处理的效果并非相加的。2. 给以低蛋白饮食使该酶缺乏的雏鸡给予肌苷没有效果。3. 放线菌素D可阻止肌苷的作用，但自身可增强黄嘌呤脱氢酶的活性。4. 在日粮中添加乳清酸后，黄嘌呤脱氢酶活性不变，而注射无机铁可刺激其活性。
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