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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

STIRPE F, DELLACORTE E

Biochem J. 1965 Feb;94(2):309-13. doi: 10.1042/bj0940309.

The xanthine-dehydrogenase activity of chick liver, expressed per mg. of nitrogen, is increased during starvation. 2. Administration of inosine and possibly of adenine has a comparable effect on the xanthine dehydrogenase, and also induces an elevation of the total quantity of enzyme. Hypoxanthine, xanthine, guanine, xanthosine, guanosine and adenosine are ineffective. Cortisone is equally ineffective. 3. The administration of puromycin abolishes the effect of inosine and reduces that of starvation. It is concluded that inosine induces an increased synthesis of xanthine dehydrogenase, whereas during starvation the enzyme is spared with respect to other liver proteins. 4. The hypothesis is formulated that chick-liver xanthine dehydrogenase is an adaptive enzyme, its activity being regulated by inosine or by one of its metabolites.

以每毫克氮计算，饥饿期间鸡肝脏中的黄嘌呤脱氢酶活性会增加。2. 给予肌苷以及可能的腺嘌呤对黄嘌呤脱氢酶有类似作用，并且还会使酶的总量升高。次黄嘌呤、黄嘌呤、鸟嘌呤、黄苷、鸟苷和腺苷均无效。可的松同样无效。3. 给予嘌呤霉素可消除肌苷的作用，并降低饥饿的作用。得出的结论是，肌苷诱导黄嘌呤脱氢酶的合成增加，而在饥饿期间，相对于其他肝脏蛋白质，该酶受到了保护。4. 提出的假设是，鸡肝脏黄嘌呤脱氢酶是一种适应性酶，其活性受肌苷或其一种代谢产物调节。

STIRPE F, DELLACORTE E

Biochem J. 1965 Feb;94(2):309-13. doi: 10.1042/bj0940309.

The xanthine-dehydrogenase activity of chick liver, expressed per mg. of nitrogen, is increased during starvation. 2. Administration of inosine and possibly of adenine has a comparable effect on the xanthine dehydrogenase, and also induces an elevation of the total quantity of enzyme. Hypoxanthine, xanthine, guanine, xanthosine, guanosine and adenosine are ineffective. Cortisone is equally ineffective. 3. The administration of puromycin abolishes the effect of inosine and reduces that of starvation. It is concluded that inosine induces an increased synthesis of xanthine dehydrogenase, whereas during starvation the enzyme is spared with respect to other liver proteins. 4. The hypothesis is formulated that chick-liver xanthine dehydrogenase is an adaptive enzyme, its activity being regulated by inosine or by one of its metabolites.

以每毫克氮计算，饥饿期间鸡肝脏中的黄嘌呤脱氢酶活性会增加。2. 给予肌苷以及可能的腺嘌呤对黄嘌呤脱氢酶有类似作用，并且还会使酶的总量升高。次黄嘌呤、黄嘌呤、鸟嘌呤、黄苷、鸟苷和腺苷均无效。可的松同样无效。3. 给予嘌呤霉素可消除肌苷的作用，并降低饥饿的作用。得出的结论是，肌苷诱导黄嘌呤脱氢酶的合成增加，而在饥饿期间，相对于其他肝脏蛋白质，该酶受到了保护。4. 提出的假设是，鸡肝脏黄嘌呤脱氢酶是一种适应性酶，其活性受肌苷或其一种代谢产物调节。