鸡肝脏中黄嘌呤脱氢酶的调节。饥饿以及嘌呤和嘌呤核苷给药的影响。
REGULATION OF XANTHINE DEHYDROGENASE IN CHICK LIVER. EFFECT OF STARVATION AND OF ADMINISTRATION OF PURINES AND PURINE NUCLEOSIDES.
作者信息
STIRPE F, DELLACORTE E
出版信息
Biochem J. 1965 Feb;94(2):309-13. doi: 10.1042/bj0940309.
Abstract
- The xanthine-dehydrogenase activity of chick liver, expressed per mg. of nitrogen, is increased during starvation. 2. Administration of inosine and possibly of adenine has a comparable effect on the xanthine dehydrogenase, and also induces an elevation of the total quantity of enzyme. Hypoxanthine, xanthine, guanine, xanthosine, guanosine and adenosine are ineffective. Cortisone is equally ineffective. 3. The administration of puromycin abolishes the effect of inosine and reduces that of starvation. It is concluded that inosine induces an increased synthesis of xanthine dehydrogenase, whereas during starvation the enzyme is spared with respect to other liver proteins. 4. The hypothesis is formulated that chick-liver xanthine dehydrogenase is an adaptive enzyme, its activity being regulated by inosine or by one of its metabolites.
摘要
- 以每毫克氮计算，饥饿期间鸡肝脏中的黄嘌呤脱氢酶活性会增加。2. 给予肌苷以及可能的腺嘌呤对黄嘌呤脱氢酶有类似作用，并且还会使酶的总量升高。次黄嘌呤、黄嘌呤、鸟嘌呤、黄苷、鸟苷和腺苷均无效。可的松同样无效。3. 给予嘌呤霉素可消除肌苷的作用，并降低饥饿的作用。得出的结论是，肌苷诱导黄嘌呤脱氢酶的合成增加，而在饥饿期间，相对于其他肝脏蛋白质，该酶受到了保护。4. 提出的假设是，鸡肝脏黄嘌呤脱氢酶是一种适应性酶，其活性受肌苷或其一种代谢产物调节。
相似文献
1
REGULATION OF XANTHINE DEHYDROGENASE IN CHICK LIVER. EFFECT OF STARVATION AND OF ADMINISTRATION OF PURINES AND PURINE NUCLEOSIDES.鸡肝脏中黄嘌呤脱氢酶的调节。饥饿以及嘌呤和嘌呤核苷给药的影响。
Biochem J. 1965 Feb;94(2):309-13. doi: 10.1042/bj0940309.
2
NUTRITION OF "ADENINELESS" AUXOTROPHS OF YEASTS.酵母“无腺嘌呤”营养缺陷型的营养
J Bacteriol. 1964 Aug;88(2):339-45. doi: 10.1128/jb.88.2.339-345.1964.
3
Profiles of purine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers.马铃薯（Solanum tuberosum L.）块茎圆盘内嘌呤生物合成、补救途径及降解的概况
Planta. 2006 Dec;225(1):115-26. doi: 10.1007/s00425-006-0334-9. Epub 2006 Jul 15.
4
Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis.大鼠实验性肾病期间的肾脏嘌呤流出及黄嘌呤氧化酶活性：嘌呤霉素氨基核苷肾病与阿霉素肾病的差异
Clin Sci (Lond). 1990 Mar;78(3):283-93. doi: 10.1042/cs0780283.
5
6
Purine metabolites and pyrimidine bases in cerebrospinal fluid of children with simple febrile seizures.单纯性热性惊厥患儿脑脊液中的嘌呤代谢产物及嘧啶碱基
Dev Med Child Neurol. 1991 Oct;33(10):908-11. doi: 10.1111/j.1469-8749.1991.tb14801.x.
7
INHIBITION OF PRUINE PHOSPHORIBOSYLTRANSFERASES OF EHRLICH ASCITES-TUMOUR CELLS BY 6-MERCAPTOPURINE.6-巯基嘌呤对艾氏腹水癌细胞嘌呤磷酸核糖转移酶的抑制作用
Biochem J. 1965 Jan;94(1):64-70. doi: 10.1042/bj0940064.
8
9
ANTAGONISM BETWEEN PURINES IN PURINE-REQUIRING BACILLUS SUBTILIS MUTANTS.嘌呤需求型枯草芽孢杆菌突变体中嘌呤之间的拮抗作用。
Arch Biochem Biophys. 1964 Dec;108:398-402. doi: 10.1016/0003-9861(64)90419-9.
10
Preservation of red blood cells with purines and nucleosides. II. Uptake and utilization of purines and nucleosides by stored red blood cells.用嘌呤和核苷保存红细胞。II. 储存红细胞对嘌呤和核苷的摄取与利用
Folia Haematol Int Mag Klin Morphol Blutforsch. 1980;107(3):417-33.
引用本文的文献
1
A Review of Emerging Goose Astrovirus Causing Gout.新兴鹅星状病毒引起痛风的研究综述。
Biomed Res Int. 2022 Aug 28;2022:1635373. doi: 10.1155/2022/1635373. eCollection 2022.
2
Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees.健康体检者血浆黄嘌呤氧化还原酶活性增高与胰岛素抵抗的关系
Sci Rep. 2022 Jun 18;12(1):10281. doi: 10.1038/s41598-022-11094-y.
3
Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research.高尿酸血症、黄嘌呤氧化还原酶与植物源核糖体失活蛋白：菲奥伦佐·斯特尔佩对前沿研究的贡献
Molecules. 2017 Jan 27;22(2):206. doi: 10.3390/molecules22020206.
4
Subcellular localization of chicken liver xanthine dehydrogenase. A possible source of cytoplasmic reducing equivalents.鸡肝黄嘌呤脱氢酶的亚细胞定位。细胞质还原当量的一个可能来源。
Biochem J. 1982 Feb 15;202(2):555-8. doi: 10.1042/bj2020555.
5
Regulation of xanthine dehydrogenase in chick liver. Further experiments on the effects of inosine, actinomycin D and other factors.鸡肝中黄嘌呤脱氢酶的调节。关于肌苷、放线菌素D及其他因素作用的进一步实验。
Biochem J. 1967 Feb;102(2):520-4. doi: 10.1042/bj1020520.
6
Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency.次黄嘌呤-鸟嘌呤磷酸核糖转移酶缺乏症中嘌呤生物合成过多的机制。
J Clin Invest. 1970 May;49(5):968-78. doi: 10.1172/JCI106316.
7
[Regulation of cholesterol synthesis].[胆固醇合成的调节]
Naturwissenschaften. 1969 Aug;56(8):398-405. doi: 10.1007/BF00593615.
8
The regulation of L-asparaginase activity in rats and mice. Effects of normal and malignant growth, of sex and of dietary changes.大鼠和小鼠中L-天冬酰胺酶活性的调节。正常生长与恶性生长、性别及饮食变化的影响。
Biochem J. 1969 Nov;115(3):597-601. doi: 10.1042/bj1150597.
本文引用的文献
1
The specificity of xanthine oxidase.黄嘌呤氧化酶的特异性。
Biochem J. 1938 Mar;32(3):494-502. doi: 10.1042/bj0320494.
2
Studies on Xanthine Oxidase: The Specificity of the System.黄嘌呤氧化酶的研究：该系统的特异性
Biochem J. 1926;20(4):703-18. doi: 10.1042/bj0200703.
3
The enzymic oxidation and assay of adenine.腺嘌呤的酶促氧化及测定
Biochem J. 1952 Jan;50(3):404-7. doi: 10.1042/bj0500404.
4
A relationship of vitamin E to nucleic acid metabolism.维生素E与核酸代谢的关系。
J Biol Chem. 1951 Dec;193(2):743-7.
5
De novo synthesis of hypoxanthine via inosine-5-phosphate and inosine.通过5-磷酸次黄苷和次黄苷从头合成次黄嘌呤。
J Biol Chem. 1951 Jun;190(2):611-31.
6
Xanthine oxidase in different species.不同物种中的黄嘌呤氧化酶。
Proc Soc Exp Biol Med. 1951 Feb;76(2):252-4. doi: 10.3181/00379727-76-18452.
7
Xanthine oxidase and liver nitrogen variation with dietary protein.黄嘌呤氧化酶与肝脏氮随膳食蛋白质的变化
J Biol Chem. 1950 Dec;187(2):605-11.
8
Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver.禁食和无蛋白饮食对大鼠肝脏尿素循环酶水平的不同影响。
J Biol Chem. 1962 Jun;237:1921-4.
9
Adaptive characteristics of urea cycle enzymes in the rat.大鼠尿素循环酶的适应性特征
J Biol Chem. 1962 Feb;237:459-68.
10
The oxidation of reduced xanthine dehydrogenase in chicken liver.鸡肝中还原型黄嘌呤脱氢酶的氧化作用。
Biochim Biophys Acta. 1955 Feb;16(2):258-63. doi: 10.1016/0006-3002(55)90212-2.
Zotero 插件