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大鼠体内视黄醇向视黄酸的转化

Formation of retinoic acid from retinol in the rat.

作者信息

Emerick R J, Zile M, DeLuca H F

出版信息

Biochem J. 1967 Feb;102(2):606-11. doi: 10.1042/bj1020606.

DOI:10.1042/bj1020606
PMID:6029617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1270286/
Abstract
  1. The formation in vivo of retinoic acid from microgram quantities of intrajugularly administered [15-(14)C]retinol was demonstrated in the rat. 2. Endogenously formed retinoic acid (about 0.1mug./rat) was found in liver, and to a much smaller extent in intestine, 12hr. after retinol administration. 3. Excretion of some of the endogenously formed retinoic acid occurred in the bile of bile-duct-cannulated rats. 4. Excretion of unaltered retinoic acid in the urine of intact rats did not occur even after the intrajugular administration of preformed retinoic acid.
摘要
  1. 在大鼠体内证明了从微克量经颈内静脉注射的[15-(14)C]视黄醇形成视黄酸。2. 视黄醇给药12小时后，在肝脏中发现了内源性形成的视黄酸（约0.1微克/大鼠），在肠道中的含量则少得多。3. 胆管插管大鼠的胆汁中出现了一些内源性形成的视黄酸的排泄。4. 即使经颈内静脉注射预先形成的视黄酸，完整大鼠的尿液中也不会出现未改变的视黄酸的排泄。

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1
Formation of retinoic acid from retinol in the rat.大鼠体内视黄醇向视黄酸的转化
Biochem J. 1967 Feb;102(2):606-11. doi: 10.1042/bj1020606.
2
Formation and enterohepatic circulation of metabolites of retinol and retinoic acid in bile duct-cannulated rats.胆管插管大鼠中视黄醇和视黄酸代谢产物的形成及肠肝循环
J Lipid Res. 1966 Jan;7(1):3-9.
3
Inhibition of retinol oxidation by ethanol in the rat liver and colon.乙醇对大鼠肝脏和结肠中视黄醇氧化的抑制作用。
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Regulation of hepatic lecithin: retinol acyltransferase activity by retinoic acid.视黄酸对肝脏卵磷脂：视黄醇酰基转移酶活性的调节
Arch Biochem Biophys. 1993 Mar;301(2):221-7. doi: 10.1006/abbi.1993.1137.
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Pathways of absorption of retinal and retinoic acid in the rat.大鼠中视黄醛和视黄酸的吸收途径
J Lipid Res. 1968 Jan;9(1):103-9.
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Pathways of retinol and retinoic acid metabolism in the rat.大鼠体内视黄醇和视黄酸的代谢途径。
Biochem J. 1967 Feb;102(2):600-5. doi: 10.1042/bj1020600.
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Rate of metabolism of retinol and retinoic acid-maintained rats after a single dose of radioactive retinol.
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Retinoic acid regulates retinol metabolism via feedback inhibition of retinol oxidation and stimulation of retinol esterification in ferret liver.视黄酸通过对雪貂肝脏中视黄醇氧化的反馈抑制和视黄醇酯化的刺激来调节视黄醇代谢。
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Metabolism, plasma transport and biliary excretion of radioactive vitamin A and its metabolites as a function of liver reserves of vitamin A in the rat.放射性维生素A及其代谢产物的代谢、血浆转运和胆汁排泄与大鼠肝脏维生素A储备的关系。
J Nutr. 1984 Jul;114(7):1327-33. doi: 10.1093/jn/114.7.1327.
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Terminal-group oxidation of retinol by mouse epidermis. Inhibition in vitro and in vivo.小鼠表皮对视黄醇的末端基团氧化作用。体内外抑制作用。
Biochem J. 1987 Jun 1;244(2):489-92. doi: 10.1042/bj2440489.

引用本文的文献

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Vitamin A - discovery, metabolism, receptor signaling and effects on bone mass and fracture susceptibility.维生素 A - 发现、代谢、受体信号转导以及对骨量和骨折易感性的影响。
Front Endocrinol (Lausanne). 2024 Apr 22;15:1298851. doi: 10.3389/fendo.2024.1298851. eCollection 2024.
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Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos.发育中的脊椎动物胚胎中维生素A的酶促代谢
Nutrients. 2016 Dec 15;8(12):812. doi: 10.3390/nu8120812.
3
Retinoic Acid Synthesis and Degradation.视黄酸的合成与降解
Subcell Biochem. 2016;81:127-161. doi: 10.1007/978-94-024-0945-1_5.
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Binding of all-trans-retinoic acid to MLTC-1 proteins.全反式维甲酸与MLTC-1蛋白的结合。
Mol Cell Biochem. 2005 Aug;276(1-2):55-60. doi: 10.1007/s11010-005-2845-2.
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All-trans-retinol is a ligand for the retinoic acid receptors.全反式视黄醇是维甲酸受体的一种配体。
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7293-7. doi: 10.1073/pnas.90.15.7293.
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Metabolism of retinoic acid in vivo in the vitamin A-deficient rat.维生素A缺乏大鼠体内视黄酸的代谢
Biochem J. 1982 Jul 15;206(1):33-41. doi: 10.1042/bj2060033.
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Characterization of retinoyl beta-glucuronide as a minor metabolite of retinoic acid in bile.视黄酰β-葡萄糖醛酸苷作为胆汁中视黄酸的一种次要代谢产物的特性研究。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3230-3. doi: 10.1073/pnas.77.6.3230.
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Retinoic acid: topical treatment of senile or actinic keratoses and basal cell carcinomas.维甲酸：用于老年性或光化性角化病及基底细胞癌的局部治疗。
Agents Actions. 1970 Aug;1(4):172-5. doi: 10.1007/BF01965758.
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Studies on the in vivo metabolism of retinoic acid in the rat.大鼠体内视黄酸代谢的研究。
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Prophylaxis of chemically induced papillomas and carcinomas of mouse skin by vitamin A-acid.维生素A酸对化学诱导的小鼠皮肤乳头瘤和癌的预防作用
Experientia. 1972 Oct 15;28(10):1219-20. doi: 10.1007/BF01946181.

本文引用的文献

1
A biologically active metabolite of retinoic acid from rat liver.一种来自大鼠肝脏的视黄酸生物活性代谢物。
Biochem J. 1965 Oct;97(1):180-6. doi: 10.1042/bj0970180.
2
THE BIOLOGICAL FUNCTION OF VITAMIN A ACID.视黄酸的生物学功能
Proc Natl Acad Sci U S A. 1960 May;46(5):587-608. doi: 10.1073/pnas.46.5.587.
3
Determination of vitamin A acid in human plasma after oral administration.口服给药后人体血浆中维甲酸的测定。
Arch Biochem Biophys. 1962 Aug;98:337-41. doi: 10.1016/0003-9861(62)90192-3.
4
SIMPLE, MULTIBORE COLUMNS FOR SUPERIOR FRACTIONATION OF LIPIDS.用于脂质高效分离的简单多孔柱
Anal Biochem. 1964 Nov;9:303-9. doi: 10.1016/0003-2697(64)90188-5.
5
IDENTIFICATION OF FREE AND CONJUGATED RETINOIC ACID AS A PRODUCT OF RETINAL (VITAMIN A ALDEHYDE) METABOLISM IN THE RAT IN VIVO.体内大鼠中视黄醛（维生素A醛）代谢产物游离及结合视黄酸的鉴定
Biochim Biophys Acta. 1964 Aug 19;90:432-4. doi: 10.1016/0304-4165(64)90218-1.
6
BIOSYNTHESIS OF L-SERINE ETHANOLAMINE PHOSPHODIESTER.L-丝氨酸乙醇胺磷酸二酯的生物合成
Nature. 1964 Jul 25;203:410. doi: 10.1038/203410a0.
7
HISTOLOGY OF THE LESIONS PRODUCED IN THE REPRODUCTIVE TRACT OF ANIMALS FED A DIET DEFICIENT IN VITAMIN A ALCOHOL BUT CONTAINING VITAMIN A ACID. II. THE FEMALE RAT.用缺乏维生素A醇但含有维生素A酸的日粮喂养的动物生殖系统中产生的病变的组织学。II. 雌性大鼠。
J Reprod Fertil. 1964 Apr;7:251-8. doi: 10.1530/jrf.0.0070251.
8
VITAMIN A AND REPRODUCTION IN RATS.维生素A与大鼠繁殖
Proc R Soc Lond B Biol Sci. 1964 Feb 18;159:510-35. doi: 10.1098/rspb.1964.0017.
9
ACTION OF VITAMIN A ON LIVER HOMOGENATE OXIDATION OF TRICARBOXYLIC ACID CYCLE INTERMEDIATES.维生素A对三羧酸循环中间产物肝脏匀浆氧化的作用
J Nutr. 1963 Dec;81:383-6. doi: 10.1093/jn/81.4.383.
10
Metabolism and biological activity of vitamin A acid in the chick.雏鸡体内视黄酸的代谢与生物活性
J Nutr. 1963 Apr;79(4):503-10. doi: 10.1093/jn/79.4.503.