大鼠体内视黄醇向视黄酸的转化
Formation of retinoic acid from retinol in the rat.
作者信息
Emerick R J, Zile M, DeLuca H F
出版信息
Biochem J. 1967 Feb;102(2):606-11. doi: 10.1042/bj1020606.
Abstract
- The formation in vivo of retinoic acid from microgram quantities of intrajugularly administered [15-(14)C]retinol was demonstrated in the rat. 2. Endogenously formed retinoic acid (about 0.1mug./rat) was found in liver, and to a much smaller extent in intestine, 12hr. after retinol administration. 3. Excretion of some of the endogenously formed retinoic acid occurred in the bile of bile-duct-cannulated rats. 4. Excretion of unaltered retinoic acid in the urine of intact rats did not occur even after the intrajugular administration of preformed retinoic acid.
摘要
- 在大鼠体内证明了从微克量经颈内静脉注射的[15-(14)C]视黄醇形成视黄酸。2. 视黄醇给药12小时后，在肝脏中发现了内源性形成的视黄酸（约0.1微克/大鼠），在肠道中的含量则少得多。3. 胆管插管大鼠的胆汁中出现了一些内源性形成的视黄酸的排泄。4. 即使经颈内静脉注射预先形成的视黄酸，完整大鼠的尿液中也不会出现未改变的视黄酸的排泄。
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