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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Biochemistry, University of Wisconsin, Madison, Wis. 53706, U.S.A.

Biochem J. 1965 Oct;97(1):180-6. doi: 10.1042/bj0970180.

Four major radioactive fractions have been isolated from the livers of vitamin A-deficient rats given [6,7-(14)C(2)]retinoic acid. 2. At least one of these was more potent than retinoic acid and approximately equal to retinol in the growth assay for vitamin A activity. 3. The biologically active material was chromatographically distinct from retinoic acid, retinol and retinal. 4. Alkaline hydrolysis of this material yielded an acidic compound containing all the radioactivity. 5. The methyl ester of the acidic product was unlike the methyl ester of retinoic acid in its chromatographic behaviour. 6. It is suggested that this metabolite may represent the active form of retinol in its growth-supporting role.

从给予[6,7-(14)C₂]视黄酸的维生素A缺乏大鼠的肝脏中分离出了四种主要的放射性组分。2. 其中至少一种在维生素A活性的生长测定中比视黄酸更有效，且在活性上与视黄醇大致相当。3. 这种生物活性物质在色谱上与视黄酸、视黄醇和视黄醛不同。4. 该物质的碱性水解产生了一种含有所有放射性的酸性化合物。5. 酸性产物的甲酯在色谱行为上与视黄酸的甲酯不同。6. 有人提出，这种代谢物可能代表视黄醇在其生长支持作用中的活性形式。

Department of Biochemistry, University of Wisconsin, Madison, Wis. 53706, U.S.A.

Biochem J. 1965 Oct;97(1):180-6. doi: 10.1042/bj0970180.

Four major radioactive fractions have been isolated from the livers of vitamin A-deficient rats given [6,7-(14)C(2)]retinoic acid. 2. At least one of these was more potent than retinoic acid and approximately equal to retinol in the growth assay for vitamin A activity. 3. The biologically active material was chromatographically distinct from retinoic acid, retinol and retinal. 4. Alkaline hydrolysis of this material yielded an acidic compound containing all the radioactivity. 5. The methyl ester of the acidic product was unlike the methyl ester of retinoic acid in its chromatographic behaviour. 6. It is suggested that this metabolite may represent the active form of retinol in its growth-supporting role.

从给予[6,7-(14)C₂]视黄酸的维生素A缺乏大鼠的肝脏中分离出了四种主要的放射性组分。2. 其中至少一种在维生素A活性的生长测定中比视黄酸更有效，且在活性上与视黄醇大致相当。3. 这种生物活性物质在色谱上与视黄酸、视黄醇和视黄醛不同。4. 该物质的碱性水解产生了一种含有所有放射性的酸性化合物。5. 酸性产物的甲酯在色谱行为上与视黄酸的甲酯不同。6. 有人提出，这种代谢物可能代表视黄醇在其生长支持作用中的活性形式。