大鼠体内视黄醇和视黄酸的代谢途径。
Pathways of retinol and retinoic acid metabolism in the rat.
作者信息
Roberts A B, DeLuca H F
出版信息
Biochem J. 1967 Feb;102(2):600-5. doi: 10.1042/bj1020600.
Abstract
- The metabolism of retinoic acid and retinyl acetate labelled with (14)C in various positions was studied after intravenous injection of physiological amounts of these compounds into retinol-deficient rats. 2. Analysis of the resultant radio-activity in the urine, carbon dioxide and faeces led to a postulation of the existence of three major pathways for the metabolism of these two compounds. 3. Evidence is presented that retinoic acid and retinol are metabolized by either the same or at least similar pathways and that retinol becomes oxidized to the carboxyl state before any degradation of the isoprenoid side chain occurs. 4. It is not possible to decide from these data whether retinoic acid is an intermediate in the retinol pathway. 5. Possible sites for the regulation of retinol metabolism are discussed.
摘要
- 将生理剂量的这些化合物静脉注射到维生素A缺乏的大鼠体内后，研究了不同位置标记有（14）C的视黄酸和醋酸视黄酯的代谢情况。2. 对尿液、二氧化碳和粪便中产生的放射性进行分析后，推测这两种化合物的代谢存在三种主要途径。3. 有证据表明视黄酸和视黄醇通过相同或至少相似的途径进行代谢，并且在类异戊二烯侧链发生任何降解之前，视黄醇会被氧化为羧基状态。4. 根据这些数据无法确定视黄酸是否是视黄醇途径中的中间体。5. 讨论了视黄醇代谢调节的可能位点。
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