放线菌素D对小鼠肝脏皮质醇及糖原生成的葡萄糖刺激作用的不同影响。
Divergent effects of actinomycin d on cortisol and on glucose stimulation of glycogenesis in mouse liver.
作者信息
Sie H G, Hablanian A, Fishman W H
出版信息
Biochem J. 1967 Jan;102(1):103-9. doi: 10.1042/bj1020103.
Abstract
- The administration of cortisol and of other glucocorticoid steroids to starved mice produced an increase in liver glycogen content, an elevation of glycogen-synthetase activity and a predominantly particulate localization of both phosphorylase and glycogen-synthetase enzymes. 2. Three daily doses of actinomycin D caused a marked glycogen depletion, a significant decrease in glycogen-synthetase activity, the solubilization of phosphorylase and glycogen synthetase and the following effects on the activities of various other enzymes: a decrease in UDP-glucose pyrophosphorylase and phosphoglucomutase, an increase in glucose 6-phosphate dehydrogenase and no change in glucose 6-phosphatase, 6-phosphogluconate dehydrogenase, pyruvate kinase and UDP-glucose dehydrogenase. 3. Glucose ingestion, but not cortisol administration, reversed the effects of actinomycin D on liver glycogen content and on the activities of phosphorylase and glycogen synthetase.
摘要
- 给饥饿小鼠注射皮质醇和其他糖皮质激素会使肝脏糖原含量增加、糖原合成酶活性升高，且磷酸化酶和糖原合成酶主要定位于微粒体。2. 连续三天给予放线菌素D会导致明显的糖原耗竭、糖原合成酶活性显著降低、磷酸化酶和糖原合成酶溶解，并对其他各种酶的活性产生以下影响：尿苷二磷酸葡萄糖焦磷酸化酶和磷酸葡萄糖变位酶活性降低，葡萄糖6-磷酸脱氢酶活性增加，而葡萄糖6-磷酸酶、6-磷酸葡萄糖酸脱氢酶、丙酮酸激酶和尿苷二磷酸葡萄糖脱氢酶活性无变化。3. 摄入葡萄糖而非注射皮质醇可逆转放线菌素D对肝脏糖原含量以及磷酸化酶和糖原合成酶活性的影响。
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