乙硫氨酸处理的小鼠肝脏中糖原合成酶的耗竭及葡萄糖-6-磷酸脱氢酶的增加。
Depletion of glycogen synthetase and increase of glucose 6-phosphate dehydrogenase in livers of ethionine-treated mice.
作者信息
Sie H G, Hablanian A
机构信息
Tufts University School of Medicine and the Cancer Research Department, New England Center Hospital, Boston, Mass., U.S.A.
出版信息
Biochem J. 1965 Oct;97(1):32-6. doi: 10.1042/bj0970032.
Abstract
- Ethionine-treated mice showed a marked depletion in liver glycogen, a decrease of glycogen-synthetase activity, an increase in activity of glucose 6-phosphate dehydrogenase and the solubilization of phosphorylase. 2. The administration of cortisol or glucose did not alleviate these changes but the effect of ethionine was completely prevented in animals given methionine as well as ethionine. 3. The activities of the following enzymes were unchanged: hexokinase, glucokinase, glucose 6-phosphatase, phosphoglucomutase, 6-phosphogluconate dehydrogenase, UDP-glucose pyrophosphorylase, UDP-glucose dehydrogenase and pyruvate kinase.
摘要
- 用乙硫氨酸处理的小鼠肝脏糖原显著耗竭，糖原合成酶活性降低，6-磷酸葡萄糖脱氢酶活性增加，磷酸化酶溶解。2. 给予皮质醇或葡萄糖并不能缓解这些变化，但在同时给予蛋氨酸和乙硫氨酸的动物中，乙硫氨酸的作用被完全阻止。3. 以下酶的活性未发生变化：己糖激酶、葡萄糖激酶、6-磷酸葡萄糖磷酸酶、磷酸葡萄糖变位酶、6-磷酸葡萄糖酸脱氢酶、尿苷二磷酸葡萄糖焦磷酸化酶、尿苷二磷酸葡萄糖脱氢酶和丙酮酸激酶。
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