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大鼠齿状回的出生后发育及早期甲状腺激素治疗的影响。

The postnatal development of rat dentate gyrus and the effect of early thyroid hormone treatment.

作者信息

Seress L

出版信息

Anat Embryol (Berl). 1977 Dec 2;151(3):335-9. doi: 10.1007/BF00318935.

DOI:10.1007/BF00318935
PMID:603085
Abstract

The postnatal development of the dentate gyrus and the effect of 5 microgram/day triiodothyronine treatment was examined by means of tritiated thymidine autoradiography. The polymorph layer of the dentate gyrus is a secondary germinal layer and forms cells for the granular layer. The cell formation in the dentate gyrus was found to be nearly completed on the 21st day, but development ended only in adulthood. Thyroid-hormone treatment did not affect significantly the postnatal cell formation of the dentate gyrus, but resulted in the appearance of a great number of pycnotic cells in the granular layer.

摘要

通过氚标记胸腺嘧啶核苷放射自显影术研究了齿状回的出生后发育以及每天5微克三碘甲状腺原氨酸治疗的效果。齿状回的多形层是一个次级生发层，为颗粒层形成细胞。发现齿状回中的细胞形成在第21天几乎完成，但发育直到成年才结束。甲状腺激素治疗对齿状回出生后的细胞形成没有显著影响，但导致颗粒层中出现大量固缩细胞。

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The postnatal development of rat dentate gyrus and the effect of early thyroid hormone treatment.大鼠齿状回的出生后发育及早期甲状腺激素治疗的影响。
Anat Embryol (Berl). 1977 Dec 2;151(3):335-9. doi: 10.1007/BF00318935.
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Thyroid hormone and development of the rat hippocampus: cell acquisition in the dentate gyrus.甲状腺激素与大鼠海马体发育：齿状回中的细胞获得
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Generation of neurons in the rat dentate gyrus and hippocampus: effects of prenatal and postnatal treatment with ethanol.大鼠齿状回和海马中神经元的生成：产前和产后乙醇处理的影响。
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Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus.阻断NMDA受体可增加发育中大鼠齿状回的细胞死亡和新生。
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Adrenal steroids regulate postnatal development of the rat dentate gyrus: II. Effects of glucocorticoids and mineralocorticoids on cell birth.肾上腺类固醇调节大鼠齿状回的出生后发育：II. 糖皮质激素和盐皮质激素对细胞生成的影响。
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Divergent responses to thyroid hormone treatment of the different secondary germinal layers in the postnatal rat brain.出生后大鼠脑中不同次级生发层对甲状腺激素治疗的不同反应。
J Hirnforsch. 1978;19(5):395-403.
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Structure of the granular layer of the rat dentate gyrus. A light microscopic and Golgi study.大鼠齿状回颗粒层的结构。光镜和高尔基染色研究。
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Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus.有证据表明，在大鼠齿状回中，晚期生成的颗粒细胞并非简单地替代早期形成的神经元。
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Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections.成年大鼠齿状回中产生的颗粒细胞发出轴突投射的证据。
Exp Brain Res. 1988;72(2):399-406. doi: 10.1007/BF00250261.

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Enhanced deficits in long-term potentiation in the adult dentate gyrus with 2nd trimester ethanol consumption.妊娠中期乙醇摄入导致成年齿状回长时程增强增强缺失。
PLoS One. 2012;7(12):e51344. doi: 10.1371/journal.pone.0051344. Epub 2012 Dec 5.

本文引用的文献

1
Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions.出生后神经发生的放射自显影和组织学研究。I. 新生大鼠中掺入氚标记胸腺嘧啶核苷的细胞的动力学、迁移和转化的纵向研究，特别提及某些脑区的出生后神经发生。
J Comp Neurol. 1966 Mar;126(3):337-89. doi: 10.1002/cne.901260302.
2
Time of neuron origin in the hippocampal region. An autoradiographic study in the mouse.海马区神经元起源时间。小鼠的放射自显影研究。
Exp Neurol Suppl. 1965 Oct:Suppl 2:1-70.
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Effect of thyroid hormone on the biochemical maturation of rat brain: postnatal cell formation.
甲状腺激素对大鼠脑生化成熟的影响：出生后细胞形成
Brain Res. 1971 Feb 5;25(3):555-70. doi: 10.1016/0006-8993(71)90460-4.
4
Comparative effects of hypothyroidism, hyperthyroidism and undernutrition on the protein and nucleic acid contents of the cerebellum in the young rat.甲状腺功能减退、甲状腺功能亢进和营养不良对幼鼠小脑蛋白质和核酸含量的比较影响。
J Neurochem. 1973 Oct;21(4):861-71. doi: 10.1111/j.1471-4159.1973.tb07530.x.
5
Radiation-induced interference with postnatal hippocampal cytogenesis in rats and its long-term effects on the acquisition of neurons and glia.辐射对大鼠出生后海马细胞生成的干扰及其对神经元和神经胶质细胞获得的长期影响。
J Comp Neurol. 1975 Sep;163(1):1-19. doi: 10.1002/cne.901630102.
6
An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the rat.大鼠齿状回颗粒细胞起源时间及迁移模式的放射自显影研究。
J Comp Neurol. 1975 Jan 15;159(2):149-75. doi: 10.1002/cne.901590202.