Maharaj R J, Thompson M, Brock-Utne J G, Williamson R, Downing J W
S Afr Med J. 1983 Apr 30;63(18):691-4.
Labetalol, a new adrenergic receptor antagonist, has both alpha- and beta-blocking properties. Intravenous labetalol (0.25 and 0.5 mg/kg), practolol (0.4 mg/kg) and saline (1 ml), injected prior to anaesthesia, were compared with respect to their effect on the haemodynamic consequences of direct laryngoscopy followed by the passage of an endotracheal tube. When compared with intravenous saline injection, both labetalol and practolol obtunded the tachycardia induced by endotracheal intubation. The higher dose of labetalol was more effective in reducing the hypertensive response than the lower dose of practolol. However, none of the regimens completely abolished the adverse haemodynamic consequences of laryngotracheal manipulations.
拉贝洛尔是一种新型肾上腺素能受体拮抗剂，具有α和β受体阻滞特性。在麻醉前静脉注射拉贝洛尔（0.25和0.5毫克/千克）、心得宁（0.4毫克/千克）和生理盐水（1毫升），比较它们对直接喉镜检查及随后插入气管导管所引起的血流动力学变化的影响。与静脉注射生理盐水相比，拉贝洛尔和心得宁均可减轻气管插管引起的心动过速。高剂量拉贝洛尔在减轻高血压反应方面比低剂量心得宁更有效。然而，所有方案均未能完全消除咽喉气管操作引起的不良血流动力学变化。
