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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Cuthbertson W F, Fleming I D, Rice M S

Biochem J. 1967 May;103(2):307-15. doi: 10.1042/bj1030307.

A fungal glucamylase (alpha-1,4-glucan glucohydrolase, EC 3.2.1.3) from Aspergillus niger depresses liver glycogen stores after intraperitoneal injection into the rat. The injected enzyme rapidly disappears (within about 8hr.) from the serum; less than 1% is excreted in the urine, but it is rapidly taken up in the liver, spleen, kidney, cardiac and skeletal muscle. Elevated glucamylase concentrations could be demonstrated in liver and spleen tissues for 1-4 days after injection, but in kidney, cardiac and skeletal muscle elevated glucamylase concentrations could be shown only for periods of less than 24hr. after injection of the enzyme.

黑曲霉的一种真菌葡糖淀粉酶（α-1,4-葡聚糖葡糖水解酶，EC 3.2.1.3）经腹腔注射到大鼠体内后会降低肝脏糖原储备。注射的酶在血清中迅速消失（约8小时内）；不到1%经尿液排出，但它会迅速被肝脏、脾脏、肾脏、心脏和骨骼肌摄取。注射后1至4天，肝脏和脾脏组织中可检测到葡糖淀粉酶浓度升高，但在肾脏、心脏和骨骼肌中，仅在注射酶后不到24小时的时间段内可显示葡糖淀粉酶浓度升高。

Cuthbertson W F, Fleming I D, Rice M S

Biochem J. 1967 May;103(2):307-15. doi: 10.1042/bj1030307.

A fungal glucamylase (alpha-1,4-glucan glucohydrolase, EC 3.2.1.3) from Aspergillus niger depresses liver glycogen stores after intraperitoneal injection into the rat. The injected enzyme rapidly disappears (within about 8hr.) from the serum; less than 1% is excreted in the urine, but it is rapidly taken up in the liver, spleen, kidney, cardiac and skeletal muscle. Elevated glucamylase concentrations could be demonstrated in liver and spleen tissues for 1-4 days after injection, but in kidney, cardiac and skeletal muscle elevated glucamylase concentrations could be shown only for periods of less than 24hr. after injection of the enzyme.

黑曲霉的一种真菌葡糖淀粉酶（α-1,4-葡聚糖葡糖水解酶，EC 3.2.1.3）经腹腔注射到大鼠体内后会降低肝脏糖原储备。注射的酶在血清中迅速消失（约8小时内）；不到1%经尿液排出，但它会迅速被肝脏、脾脏、肾脏、心脏和骨骼肌摄取。注射后1至4天，肝脏和脾脏组织中可检测到葡糖淀粉酶浓度升高，但在肾脏、心脏和骨骼肌中，仅在注射酶后不到24小时的时间段内可显示葡糖淀粉酶浓度升高。