Wujanz G, Agahd S
Arch Exp Veterinarmed. 1977;31(5):633-42.
Subclinical moderate to medium haemolytic anaemia may be produced in cattle by intravenous slow drip infusion of erythrozyte-specific serum with immune antibody. Anisocytosis may be caused to appear in the blood count even by low-quantity intravenous application of iso-immune serum. Increase in serum quantity will lead to predominance of small erythrocytes (microspherocytes). The Price-Jones curve is likely to shift to the left and will flatten. The detection of microspherocytes actually reflects an antigen-antibody reaction caused by transmission of iso-immune antibody and resulting in partial damage of the erythrocyte membrane rather than in complete erythrocytolysis. The absence of both haemoglobinaemia and haemoglobinuria seems to support the assumption that premature degradation of the damaged erythrocytes takes place extravasally in the reticulohistiocytary system.
通过静脉缓慢滴注含有免疫抗体的红细胞特异性血清，可在牛身上引发亚临床中度至重度溶血性贫血。即使静脉注射少量同种免疫血清，血细胞计数中也可能出现红细胞大小不均。血清量增加会导致小红细胞（小球形红细胞）占优势。普赖斯-琼斯曲线可能向左移动并变平。小球形红细胞的检测实际上反映了同种免疫抗体传递引起的抗原-抗体反应，导致红细胞膜部分受损而非完全溶血。无血红蛋白血症和血红蛋白尿似乎支持这样的假设，即受损红细胞的过早降解发生在网状组织细胞系统的血管外。
