Geller J, Albert J, Lopez D, Geller S, Niwayama G
J Clin Endocrinol Metab. 1976 Sep;43(3):686-8. doi: 10.1210/jcem-43-3-686.
5 alpha-Dihydrotestosterone (DHT) and androstanediols (diols) have been measured in human prostate tissue. DHT levels in surgical specimens of prostate from 8 patients with BPH averaged 5.6 +/- 0.93 S.E. ng/g and were significantly greater than (P less than 0.01) values of 2.1 +/- 0.32 S.E. ng/g in 6 normal prostates obtained post-mortem from males less than 50 yrs old. Androstanediols averaged 2.3 +/- 0.35 S.E. ng/g in the BPH specimens compared to values of 10.2 +/- 2.4 S.E. ng/g in the normal prostates (P less than 0.01). This significantly higher (P less than 0.001) ratio of diols/DHT in the normal (5.1 +/- 0.93 S.E.) compared to the BPH prostate (0.45 +/- 0.08 S.E.) suggests that a decrease in 3-hydroxysteroid oxido-reductase, which converts DHT to diol, may be an important clue to the pathogenesis of BPH.
已对人体前列腺组织中的5α - 二氢睾酮（DHT）和雄甾二醇（二醇）进行了测量。8例良性前列腺增生（BPH）患者前列腺手术标本中的DHT水平平均为5.6±0.93标准误纳克/克，显著高于（P＜0.01）6例50岁以下男性死后获得的正常前列腺中2.1±0.32标准误纳克/克的值。BPH标本中雄甾二醇平均为2.3±0.35标准误纳克/克，而正常前列腺中的值为10.2±2.4标准误纳克/克（P＜0.01）。与BPH前列腺（0.45±0.08标准误）相比，正常前列腺中二醇/DHT的这一显著更高的比例（P＜0.001）（5.1±0.93标准误）表明，将DHT转化为二醇的3 - 羟基类固醇氧化还原酶的减少可能是BPH发病机制的一个重要线索。
