Kriger F, Burke D, Samoiloff M R
Biochem Genet. 1977 Dec;15(11-12):1181-91. doi: 10.1007/BF00484508.
Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, with a greater recovery for branched rather than n-alcohols. Coincident with recovery is a threefold increase in alcohol dehydrogenase and aldehyde dehydrogenase activity. A model involving posttranscriptional control of the levels of these enzymes is presented.
将重生滑刃线虫置于7%的乙醇或甲醇中时，它会变得无法移动。1小时后，这些动物恢复正常游动，并能在酒精中生长。通过抑制剂研究确定，恢复能力需要乙醇脱氢酶（ADH）活性和翻译，但不需要转录。随着醇链长度增加，恢复能力下降，支链醇的恢复能力强于正醇。与恢复同时发生的是，乙醇脱氢酶和乙醛脱氢酶活性增加了三倍。本文提出了一个涉及这些酶水平的转录后控制的模型。
