黑腹果蝇中无组蛋白乙酰化的基因激活
Gene activation without histone acetylation in Drosophila melanogaster.
作者信息
Ellgaard E G
出版信息
Science. 1967 Sep 1;157(3792):1070-2. doi: 10.1126/science.157.3792.1070.
PMID:6036239
Abstract
Chromosomal puffing, generally believed to represent gene activation in Drosophila, was induced in the presence of radioactively labeled acetate. There is no preferential uptake of these labeled molecules in regions of gene activation. It is concluded that the acetylation of histones does not play a general role in the regulation of RNA synthesis in Drosophila melanogaster.
摘要
染色体疏松现象通常被认为代表果蝇中的基因激活，它是在存在放射性标记的乙酸盐的情况下诱导产生的。在基因激活区域并没有对这些标记分子的优先摄取。得出的结论是，组蛋白的乙酰化在黑腹果蝇RNA合成的调控中并不起普遍作用。
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