Narahashi T, Haas H G
Science. 1967 Sep 22;157(3795):1438-40. doi: 10.1126/science.157.3795.1438.
The falling phase of action potentials of lobster giant axons is prolonged by DDT; finally a plateau phase is produced like cardiac action potentials. In axons poisoned with DDT, peak transient (sodium) currents associated with step depolarizations are turned off very slowly, and steady-state (potassium) currents are markedly suppressed. These two changes would cause the prolongation of action potentials and are considered the major ionic mechanisms of DDT action.
滴滴涕会延长龙虾巨轴突动作电位的下降期；最终会产生一个类似心脏动作电位的平台期。在被滴滴涕毒害的轴突中，与阶跃去极化相关的峰值瞬态（钠）电流关闭得非常缓慢，而稳态（钾）电流则受到明显抑制。这两种变化会导致动作电位延长，被认为是滴滴涕作用的主要离子机制。
