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J Bacteriol. 1967 Aug;94(2):323-6. doi: 10.1128/jb.94.2.323-326.1967.
2
[Acetoin formation by Lactobacillus plantarum dependent on thiamine, lipoic acid, L-valine, and L-isoleucine].植物乳杆菌依赖硫胺素、硫辛酸、L-缬氨酸和L-异亮氨酸形成乙偶姻
Arch Mikrobiol. 1970;70(4):303-12.
3
The accumulation of acetylmethylcarbinol and acetylethylcarbinol by a mutant of Neurospora crassa and its significance in the biosynthesis of isoleucine and valine.粗糙脉孢菌突变体对乙酰甲基甲醇和乙酰乙基甲醇的积累及其在异亮氨酸和缬氨酸生物合成中的意义。
J Biol Chem. 1959 Jan;234(1):99-104.
4
Biosynthesis of compounds similar to aspergillic acid.与曲霉酸类似的化合物的生物合成。
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Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine.在L-缬氨酸存在下生长的谷氨酸棒杆菌的全基因组表达谱分析及生理特性研究
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7
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High-yield fermentative preparation of tetramethylpyrazine by Bacillus sp. using an endogenous precursor approach.利用内源性前体途径，通过芽孢杆菌属发酵制备高产量的四甲基吡嗪。
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Pyrazines responsible for the potatolike odor produced by some serratia and cedecea strains.吡嗪类化合物导致一些沙雷氏菌和西地西菌产生类似土豆的气味。
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本文引用的文献

1
Discovery of a pyrazine in a natural product: tetramethylpyrazine from cultures of a strain of Bacillus subtilis.在天然产物中发现一种吡嗪：来自一株枯草芽孢杆菌培养物的四甲基吡嗪。
Nature. 1962 Feb 24;193:776. doi: 10.1038/193776a0.
2
Evidence for two distinct enzyme systems forming acetolactate in Aerobacter aerogenes.产气气杆菌中存在两种不同的酶系统形成乙酰乳酸的证据。
J Biol Chem. 1959 Dec;234:3067-71.
3
INHIBITION OF THE BIOSYNTHESIS OF THE PYRIMIDINE PORTION OF THIAMINE BY ADENOSINE.腺苷对硫胺素嘧啶部分生物合成的抑制作用。
J Bacteriol. 1964 Oct;88(4):1024-9. doi: 10.1128/jb.88.4.1024-1029.1964.
4
[STUDIES ON THE METABOLIC PRODUCTS OF BACILLUS SUBTILIS. IV. DETERMINATION AND MECHANISM OF FORMATION OF TETRAMETHYLPYRAZINE].[枯草芽孢杆菌代谢产物的研究。IV. 四甲基吡嗪的形成机制及测定]
Yakugaku Zasshi. 1964 Jun;84:545-8.
5
GENETIC BLOCKS IN THE ISOLEUCINE-VALINE PATHWAY OF NEUROSPORA CRASSA.粗糙脉孢菌异亮氨酸-缬氨酸途径中的遗传阻断
Genetics. 1964 May;49(5):865-82. doi: 10.1093/genetics/49.5.865.
6
The accumulation of acetylmethylcarbinol and acetylethylcarbinol by a mutant of Neurospora crassa and its significance in the biosynthesis of isoleucine and valine.粗糙脉孢菌突变体对乙酰甲基甲醇和乙酰乙基甲醇的积累及其在异亮氨酸和缬氨酸生物合成中的意义。
J Biol Chem. 1959 Jan;234(1):99-104.
7
Isoleucine and valine metabolism in Escherichia coli. VIII. The formation of acetolactate.大肠杆菌中异亮氨酸和缬氨酸的代谢。VIII. 乙酰乳酸的形成。
J Biol Chem. 1958 Nov;233(5):1156-60.

异亮氨酸 - 缬氨酸途径突变伴随的硫胺素依赖性川芎嗪积累。

Thiamine-dependent accumulation of tetramethylpyrazine accompanying a mutation in the isoleucine-valine pathway.

作者信息

Demain A L, Jackson M, Trenner N R

出版信息

J Bacteriol. 1967 Aug;94(2):323-6. doi: 10.1128/jb.94.2.323-326.1967.

DOI:10.1128/jb.94.2.323-326.1967
PMID:6039355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC315043/
Abstract

A mutant of Corynebacterium glutamicum was found to accumulate high concentrations of a material which crystallized upon cooling of the broth. The compound was identified as tetramethylpyrazine. The mutant was found to require isoleucine, valine, leucine, and pantothenate for growth. All four requirements probably result from the loss of a single enzyme of the isoleucine-valine pathway. Since similar mutants of Neurospora crassa accumulate acetoin, the present mutant probably forms tetramethylpyrazine from acetoin. Accumulation of tetramethylpyrazine was dependent upon addition of thiamine. This observation is consistent with the known activity of diphosphothiamine as a cofactor for the formation of acetolactate (a precursor of acetoin) from pyruvate.

摘要

发现谷氨酸棒杆菌的一个突变体能够积累高浓度的一种物质，该物质在肉汤冷却时会结晶。该化合物被鉴定为四甲基吡嗪。发现该突变体生长需要异亮氨酸、缬氨酸、亮氨酸和泛酸盐。所有这四种需求可能是由于异亮氨酸 - 缬氨酸途径中单一酶的缺失所致。由于粗糙脉孢菌的类似突变体积累乙偶姻，目前这个突变体可能由乙偶姻形成四甲基吡嗪。四甲基吡嗪的积累依赖于硫胺素的添加。这一观察结果与已知的二磷酸硫胺素作为丙酮酸形成乙酰乳酸（乙偶姻的前体）的辅因子的活性一致。