细胞间通讯与组织生长。I. 癌性生长。
Intercellular communication and tissue growth. I. Cancerous growth.
作者信息
Loewenstein W R, Kanno Y
出版信息
J Cell Biol. 1967 May;33(2):225-34. doi: 10.1083/jcb.33.2.225.
Abstract
Intercellular communication was examined with intracellular electrical techniques in primary and transplanted rat liver cancers. Normal liver cells communicate rather freely with each other through permeable junctional membranes. Cancer liver cells show no communication at all; their surface membrane is a strong barrier to diffusion all around the cell. Cancer cells induce alterations in membrane permeability in normal liver cells; communication among the latter is markedly reduced when cancer cells grow near them.
摘要
运用细胞内电技术对原发性和移植性大鼠肝癌中的细胞间通讯进行了研究。正常肝细胞通过可渗透的连接膜彼此相当自由地进行通讯。肝癌细胞则完全没有通讯；它们的表面膜在细胞周围对扩散构成强大屏障。癌细胞会诱导正常肝细胞的膜通透性发生改变；当癌细胞在正常肝细胞附近生长时，后者之间的通讯会显著减少。
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