Reeve D R
J Anat. 1977 Dec;124(Pt 3):731-40.
Large perforations of the tympanic membrane were made in groups of guinea-pigs. The mitotic response in the stratified squamous epithelium at the edge of the wound was examined in perforations between 1 and 28 days after injury. Peaks of activity were discovered at 2, 15-16 and 24 days after wounding. It was also found that the maximal proliferative response was not at the immediate wound edge, as is usually maintained, but as some 2 mm from the wound edge. The results correspond remarkably well with work previously done by the present author on wounded rectal mucous membrane. The results are examined in the light of the chalone hypothesis of mitotic control.
在豚鼠群体中制造鼓膜大穿孔。在损伤后1至28天之间的穿孔中，检查伤口边缘复层鳞状上皮的有丝分裂反应。在受伤后第2天、第15 - 16天和第24天发现了活性峰值。还发现最大增殖反应并非如通常所认为的那样在伤口的直接边缘，而是在距伤口边缘约2毫米处。这些结果与作者先前对受伤直肠黏膜所做的工作非常吻合。根据有丝分裂控制的抑素假说对这些结果进行了研究。
