2,4-二氨基-5-(3',4'-二氯苯基)-6-甲基嘧啶（DDMP，NSC 19494）的酶抑制测定
An enzyme inhibition assay for 2,4-diamino-5-(3'4'-dichlorophenyl)-6-methylpyrimidine (DDMP,NSC 19494).
作者信息
Calvert A H, Cridland J S, Harrap K R
出版信息
J Clin Pathol. 1977 Dec;30(12):1154-7. doi: 10.1136/jcp.30.12.1154.
Abstract
An enzyme inhibiton method for the determination of serum levels of DDMP is described. This has proved to be a simple, practical, and reliable method for the clinical monitoring of patients.
摘要
本文描述了一种用于测定血清中DDMP水平的酶抑制法。事实证明，这是一种用于患者临床监测的简单、实用且可靠的方法。
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本文引用的文献
1
TECHNIQUES FOR STUDY OF RESISTANCE TO FOLIC ACID ANTAGONISTS.叶酸拮抗剂抗性研究技术
Methods Med Res. 1964;10:297-307.
2
Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid.二氨基嘧啶的二氯和一氯苯基类似物的临床效果：叶酸拮抗剂
J Clin Invest. 1954 Oct;33(10):1388-96. doi: 10.1172/JCI103016.
3
The determination of enzyme inhibitor constants.酶抑制剂常数的测定
Biochem J. 1953 Aug;55(1):170-1. doi: 10.1042/bj0550170.
4
Dihydrofolate reductase from Trypanosoma equiperdum. II. Inhibition by 2,4-diaminopyrimidines and related heterocycles.来自马媾疫锥虫的二氢叶酸还原酶。II. 2,4-二氨基嘧啶及相关杂环化合物的抑制作用
J Med Chem. 1969 Jul;12(4):662-8. doi: 10.1021/jm00304a023.
5
Quantitation of pyrimethamine and related diaminopyrimidines in situ by enhancement of fluorescence after thin layer chromatography.薄层色谱后通过荧光增强法定量测定原位乙胺嘧啶及相关二氨基嘧啶。
Anal Chem. 1973 Jul;45(8):1538-40. doi: 10.1021/ac60330a056.
6
Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.关于克服对甲氨蝶呤耐药性的研究：甲氨蝶呤与2,4 - 二氨基 - 5 -（3'，4' - 二氯苯基）- 6 - 甲基嘧啶（BW50197）对L5178Y细胞集落形成能力影响的比较
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Determination of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (BW 197U) in human plasma.人血浆中2,4-二氨基-5-(3,4-二氯苯基)-6-甲基嘧啶（BW 197U）的测定
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